Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489162948> ?p ?o ?g. }
- W1489162948 endingPage "14" @default.
- W1489162948 startingPage "2104" @default.
- W1489162948 abstract "Telomerase is a ribonucleoprotein enzyme that functions to maintain telomeres, the terminal DNA that protects chromosomal integrity, regulating cellular replicative life span. Telomerase is not expressed in most normal human somatic cells but is active in stabilizing telomeres of certain self-renewing cell populations and most malignant cells, making the enzyme an appealing target for anticancer therapy. We describe here a novel cross-species approach to telomerase inhibition. Ectopic expression of the human telomerase catalytic reverse transcriptase component in murine cells inhibited endogenous murine telomerase activity. Using this approach, telomerase inhibition in immortal murine fibroblasts resulted in critical telomere shortening, leading to slowed proliferation, abnormal morphology, altered cell cycle, and telomere dysfunction with cytogenetic instability, followed by apoptotic cell death. Subpopulations of two telomerase-inhibited clones escaped widespread apoptosis, showing proliferative recovery in culture despite persistently inhibited telomerase activity with progressive telomere shortening and dysfunction. This study, by targeting immortal murine cells for telomerase inhibition, demonstrates the importance of telomerase to murine cell immortalization and telomere maintenance. Moreover, the murine model used here should prove useful in further evaluating telomerase inhibition as an anticancer therapy." @default.
- W1489162948 created "2016-06-24" @default.
- W1489162948 creator A5003626159 @default.
- W1489162948 creator A5034713324 @default.
- W1489162948 creator A5048060846 @default.
- W1489162948 creator A5059625599 @default.
- W1489162948 creator A5086994519 @default.
- W1489162948 creator A5091124074 @default.
- W1489162948 date "2002-04-01" @default.
- W1489162948 modified "2023-09-27" @default.
- W1489162948 title "Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts." @default.
- W1489162948 cites W1496772673 @default.
- W1489162948 cites W1543500873 @default.
- W1489162948 cites W1545398558 @default.
- W1489162948 cites W1579661837 @default.
- W1489162948 cites W1612842202 @default.
- W1489162948 cites W1676646253 @default.
- W1489162948 cites W173115147 @default.
- W1489162948 cites W1750539994 @default.
- W1489162948 cites W176973267 @default.
- W1489162948 cites W1967017947 @default.
- W1489162948 cites W1968309671 @default.
- W1489162948 cites W1968325292 @default.
- W1489162948 cites W1973552223 @default.
- W1489162948 cites W1973577066 @default.
- W1489162948 cites W1976231646 @default.
- W1489162948 cites W1976273464 @default.
- W1489162948 cites W1981150156 @default.
- W1489162948 cites W1983673827 @default.
- W1489162948 cites W1986808310 @default.
- W1489162948 cites W1992934869 @default.
- W1489162948 cites W1997857277 @default.
- W1489162948 cites W2004314923 @default.
- W1489162948 cites W2006351633 @default.
- W1489162948 cites W2014231393 @default.
- W1489162948 cites W2025535668 @default.
- W1489162948 cites W2025791374 @default.
- W1489162948 cites W2026367460 @default.
- W1489162948 cites W2028125839 @default.
- W1489162948 cites W2030976397 @default.
- W1489162948 cites W2032407757 @default.
- W1489162948 cites W2038256059 @default.
- W1489162948 cites W2042125392 @default.
- W1489162948 cites W2043204829 @default.
- W1489162948 cites W2044444301 @default.
- W1489162948 cites W2049481441 @default.
- W1489162948 cites W2052260390 @default.
- W1489162948 cites W2063271191 @default.
- W1489162948 cites W2075808770 @default.
- W1489162948 cites W2078532650 @default.
- W1489162948 cites W2079378073 @default.
- W1489162948 cites W2084359613 @default.
- W1489162948 cites W2108482850 @default.
- W1489162948 cites W2110286112 @default.
- W1489162948 cites W2115346781 @default.
- W1489162948 cites W2117824620 @default.
- W1489162948 cites W2118228848 @default.
- W1489162948 cites W2119048840 @default.
- W1489162948 cites W2123111989 @default.
- W1489162948 cites W2309542863 @default.
- W1489162948 cites W2418888737 @default.
- W1489162948 cites W2424565660 @default.
- W1489162948 cites W2742636786 @default.
- W1489162948 cites W60632522 @default.
- W1489162948 cites W93289845 @default.
- W1489162948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11929832" @default.
- W1489162948 hasPublicationYear "2002" @default.
- W1489162948 type Work @default.
- W1489162948 sameAs 1489162948 @default.
- W1489162948 citedByCount "12" @default.
- W1489162948 countsByYear W14891629482015 @default.
- W1489162948 countsByYear W14891629482022 @default.
- W1489162948 crossrefType "journal-article" @default.
- W1489162948 hasAuthorship W1489162948A5003626159 @default.
- W1489162948 hasAuthorship W1489162948A5034713324 @default.
- W1489162948 hasAuthorship W1489162948A5048060846 @default.
- W1489162948 hasAuthorship W1489162948A5059625599 @default.
- W1489162948 hasAuthorship W1489162948A5086994519 @default.
- W1489162948 hasAuthorship W1489162948A5091124074 @default.
- W1489162948 hasConcept C104317684 @default.
- W1489162948 hasConcept C125593758 @default.
- W1489162948 hasConcept C134305767 @default.
- W1489162948 hasConcept C153911025 @default.
- W1489162948 hasConcept C177336024 @default.
- W1489162948 hasConcept C190283241 @default.
- W1489162948 hasConcept C502942594 @default.
- W1489162948 hasConcept C54355233 @default.
- W1489162948 hasConcept C552990157 @default.
- W1489162948 hasConcept C62112901 @default.
- W1489162948 hasConcept C67705224 @default.
- W1489162948 hasConcept C75934600 @default.
- W1489162948 hasConcept C81885089 @default.
- W1489162948 hasConcept C86803240 @default.
- W1489162948 hasConcept C94581717 @default.
- W1489162948 hasConcept C95444343 @default.
- W1489162948 hasConcept C97037327 @default.
- W1489162948 hasConceptScore W1489162948C104317684 @default.
- W1489162948 hasConceptScore W1489162948C125593758 @default.