Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489181736> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1489181736 endingPage "71" @default.
- W1489181736 startingPage "65" @default.
- W1489181736 abstract "Mice injected intravenously with a high dose (5 X 10(7) ) of BCG fail to develop delayed hypersensitivity to BCG and are described as anergic or unresponsive. Spleen cells from these mice release factors on culture which suppress DNA synthesis induced by concanavalin A in vitro. Cell separation experiments showed that both macrophages and T cells produce inhibitory factors. However, the macrophage factor has a molecular weight 10,000-30,000, while the T cell factor has a molecular weight of 50,000-70,000. Further evidence that these two factors are different is provided by the kinetics of their action. The T cell factor only acts when given within 12 hr of stimulation with concanavalin A, while the macrophage factor acts even when given at 48 hr. In the case of the T cell factor, the inhibition of DNA synthesis may be attributed to its ability to block the interleukin-2 production induced by Con A. As similar T cell and macrophage factors are produced in mice responding to simple chemically reactive haptenes (contact sensitizers), it is possible that a similar suppressor circuit is involved in the control of the response to contact sensitizers and in the production of unresponsiveness (anergy) in mice given large doses of BCG." @default.
- W1489181736 created "2016-06-24" @default.
- W1489181736 creator A5042581349 @default.
- W1489181736 creator A5053991325 @default.
- W1489181736 creator A5060813374 @default.
- W1489181736 creator A5071145958 @default.
- W1489181736 creator A5084589140 @default.
- W1489181736 date "1984-01-01" @default.
- W1489181736 modified "2023-10-18" @default.
- W1489181736 title "Suppressor cells induced by BCG release non-specific factors in vitro which inhibit DNA synthesis and interleukin-2 production." @default.
- W1489181736 cites W1532846703 @default.
- W1489181736 cites W1671126627 @default.
- W1489181736 cites W1776474765 @default.
- W1489181736 cites W1846808436 @default.
- W1489181736 cites W1968656516 @default.
- W1489181736 cites W1970247551 @default.
- W1489181736 cites W2011813455 @default.
- W1489181736 cites W2036246199 @default.
- W1489181736 cites W2056419160 @default.
- W1489181736 cites W2105804166 @default.
- W1489181736 cites W2111800917 @default.
- W1489181736 cites W2131624029 @default.
- W1489181736 cites W2158128286 @default.
- W1489181736 cites W2166072008 @default.
- W1489181736 cites W2401172688 @default.
- W1489181736 cites W2402398455 @default.
- W1489181736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1454412" @default.
- W1489181736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6228520" @default.
- W1489181736 hasPublicationYear "1984" @default.
- W1489181736 type Work @default.
- W1489181736 sameAs 1489181736 @default.
- W1489181736 citedByCount "15" @default.
- W1489181736 crossrefType "journal-article" @default.
- W1489181736 hasAuthorship W1489181736A5042581349 @default.
- W1489181736 hasAuthorship W1489181736A5053991325 @default.
- W1489181736 hasAuthorship W1489181736A5060813374 @default.
- W1489181736 hasAuthorship W1489181736A5071145958 @default.
- W1489181736 hasAuthorship W1489181736A5084589140 @default.
- W1489181736 hasConcept C104317684 @default.
- W1489181736 hasConcept C134018914 @default.
- W1489181736 hasConcept C147483822 @default.
- W1489181736 hasConcept C153911025 @default.
- W1489181736 hasConcept C179185449 @default.
- W1489181736 hasConcept C185592680 @default.
- W1489181736 hasConcept C19869320 @default.
- W1489181736 hasConcept C202751555 @default.
- W1489181736 hasConcept C203014093 @default.
- W1489181736 hasConcept C24998067 @default.
- W1489181736 hasConcept C2779244956 @default.
- W1489181736 hasConcept C3017924640 @default.
- W1489181736 hasConcept C55493867 @default.
- W1489181736 hasConcept C64241487 @default.
- W1489181736 hasConcept C86803240 @default.
- W1489181736 hasConcept C95444343 @default.
- W1489181736 hasConceptScore W1489181736C104317684 @default.
- W1489181736 hasConceptScore W1489181736C134018914 @default.
- W1489181736 hasConceptScore W1489181736C147483822 @default.
- W1489181736 hasConceptScore W1489181736C153911025 @default.
- W1489181736 hasConceptScore W1489181736C179185449 @default.
- W1489181736 hasConceptScore W1489181736C185592680 @default.
- W1489181736 hasConceptScore W1489181736C19869320 @default.
- W1489181736 hasConceptScore W1489181736C202751555 @default.
- W1489181736 hasConceptScore W1489181736C203014093 @default.
- W1489181736 hasConceptScore W1489181736C24998067 @default.
- W1489181736 hasConceptScore W1489181736C2779244956 @default.
- W1489181736 hasConceptScore W1489181736C3017924640 @default.
- W1489181736 hasConceptScore W1489181736C55493867 @default.
- W1489181736 hasConceptScore W1489181736C64241487 @default.
- W1489181736 hasConceptScore W1489181736C86803240 @default.
- W1489181736 hasConceptScore W1489181736C95444343 @default.
- W1489181736 hasIssue "1" @default.
- W1489181736 hasLocation W14891817361 @default.
- W1489181736 hasOpenAccess W1489181736 @default.
- W1489181736 hasPrimaryLocation W14891817361 @default.
- W1489181736 hasRelatedWork W1489181736 @default.
- W1489181736 hasRelatedWork W151534442 @default.
- W1489181736 hasRelatedWork W1516796836 @default.
- W1489181736 hasRelatedWork W1868745271 @default.
- W1489181736 hasRelatedWork W1983692521 @default.
- W1489181736 hasRelatedWork W1997681068 @default.
- W1489181736 hasRelatedWork W2429518082 @default.
- W1489181736 hasRelatedWork W2465802555 @default.
- W1489181736 hasRelatedWork W87428806 @default.
- W1489181736 hasRelatedWork W2015947745 @default.
- W1489181736 hasVolume "51" @default.
- W1489181736 isParatext "false" @default.
- W1489181736 isRetracted "false" @default.
- W1489181736 magId "1489181736" @default.
- W1489181736 workType "article" @default.