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- W1489187586 abstract "Fifteen years ago lin-4 was reported to be the firstendogenous small non-coding, but interfering RNA structure involvedin developmental timing in C. elegans. First thought not, or onlyrarely, to occur in mammals, microRNAs are now among the majorplayers in up-to-date genomic research. The mature molecules are~22 nucleotides in length and, by targeting predominantly the 3'UTR of mRNAs, lead to translational repression or degradation ofthe target message, hence controlling important cellularmechanisms, including division, differentiation and death. This keyrole makes them excellent targets for cancer research. In fact theyhave been shown to have a major impact on cancer development inmany cases. However, miRNAs are not a homogeneous class and can besub classified into intragenic and intergenic, depending on theirgenomic position. Whereas intergenic miRNAs are expected to beindependent transcriptional units, intragenic miRNAs are commonlybelieved to be regulated through their host gene. Despite of thegrowing knowledge on how miRNAs integrate into cellular regulatorynetworks, our current knowledge about the specific role ofintragenic miRNAs is rather limited. In this work we integratedcurrent miRNA knowledge bases, ranging from miRNA sequence andgenomic localization information to target prediction, withbiochemical pathway information and publicly available expressiondata to investigate functional properties of intragenic miRNAs andtheir relationship to their host genes. To the best of ourknowledge, we are the first to show in a large-scale analysis thatintragenic miRNAs seem to act as negative feedback regulators onmultiple levels. We furthermore investigated the impact of thismodel on the potential role of intronic miRNAs in cancerpathogenesis." @default.
- W1489187586 created "2016-06-24" @default.
- W1489187586 creator A5082178671 @default.
- W1489187586 date "2009-01-01" @default.
- W1489187586 modified "2023-09-28" @default.
- W1489187586 title "Silencing the host : the role of intronic microRNAs" @default.
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