FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489198622> ?p ?o ?g. }

• W1489198622 endingPage "1021" @default.
• W1489198622 startingPage "1016" @default.
• W1489198622 abstract "Abstract BACKGROUND The authors validated an algorithm for the preoperative prediction of lymph node (LN) metastases in patients with clinically localized prostate carcinoma. The algorithm was applied to sextant biopsy material and radical retropubic prostatectomy (RRP) stage obtained from a cohort of men who were treated at the authors' institution. METHODS Four hundred forty‐three patients underwent systematic sextant biopsy and RRP with staging lymphadenectomy. The original algorithm was based on systematic sextant biopsy data and classified patients into three risk groups for LN metastases based on the biopsy result. If ≥ 4 of 6 biopsies contained any Gleason Pattern 4 disease, then the patient was at high risk for LN metastases (45%). Patients with ≥ 1 of 6 biopsies with dominant Gleason Pattern 4 disease (excluding high‐risk patients) had an intermediate predicted risk (19%) of LN metastases. All other patients had a low predicted risk of LN metastases (2.2%). The authors assed the percentage of patients who were positive and negative for LN metastases and calculated the specificity and negative predictive value in the series when patients were classified according to the original algorithm. RESULTS Twenty of 443 patients had intraoperative LN metastases. When applied to the current data, the Hamburg algorithm classified 404 patients in the low‐risk group, 30 patients in the intermediate‐risk group, and 9 patients in the high risk group. The incidence of LN metastases was 2.47% in the low‐risk group, 20% in the intermediate‐risk group, and 44.4% in the high‐risk group. The negative predictive value for the low‐risk group was 97.52%, and the specificity was 94.14%. CONCLUSIONS The Hamburg algorithm proved a valid tool for the prediction of lymphatic spread in this validation study on data from the authors' institution. The algorithm may serve as a tool to select patients who do not need to undergo pelvic lymphadenectomy at the time they undergo RRP, hence reducing morbidity and expense. More importantly, with the increasing numbers of men undergoing treatment options in whom LN dissection is not performed, this validated algorithm provides an important selection basis regarding the appropriateness of a therapy that does not routinely include LN staging. Cancer 2002;95:1016–21. © 2002 American Cancer Society. DOI 10.1002/cncr.10811" @default.
• W1489198622 created "2016-06-24" @default.
• W1489198622 creator A5062227791 @default.
• W1489198622 creator A5063449536 @default.
• W1489198622 creator A5089012338 @default.
• W1489198622 creator A5089661293 @default.
• W1489198622 date "2002-08-19" @default.
• W1489198622 modified "2023-10-18" @default.
• W1489198622 title "Validation of a biopsy-based pathologic algorithm for predicting lymph node metastases in patients with clinically localized prostate carcinoma" @default.
• W1489198622 cites W1259141303 @default.
• W1489198622 cites W182657709 @default.
• W1489198622 cites W190857994 @default.
• W1489198622 cites W1967770117 @default.
• W1489198622 cites W1994876742 @default.
• W1489198622 cites W2020345085 @default.
• W1489198622 cites W2021486197 @default.
• W1489198622 cites W2027588785 @default.
• W1489198622 cites W2038927192 @default.
• W1489198622 cites W2039861906 @default.
• W1489198622 cites W2041101500 @default.
• W1489198622 cites W2071201227 @default.
• W1489198622 cites W2073898361 @default.
• W1489198622 cites W2081982276 @default.
• W1489198622 cites W2088740850 @default.
• W1489198622 cites W2106342858 @default.
• W1489198622 cites W2146162013 @default.
• W1489198622 cites W2158844015 @default.
• W1489198622 cites W2163276477 @default.
• W1489198622 cites W2416455276 @default.
• W1489198622 cites W4293658047 @default.
• W1489198622 cites W46295630 @default.
• W1489198622 doi "https://doi.org/10.1002/cncr.10811" @default.
• W1489198622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12209685" @default.
• W1489198622 hasPublicationYear "2002" @default.
• W1489198622 type Work @default.
• W1489198622 sameAs 1489198622 @default.
• W1489198622 citedByCount "59" @default.
• W1489198622 countsByYear W14891986222012 @default.
• W1489198622 countsByYear W14891986222013 @default.
• W1489198622 countsByYear W14891986222014 @default.
• W1489198622 countsByYear W14891986222015 @default.
• W1489198622 countsByYear W14891986222016 @default.
• W1489198622 countsByYear W14891986222018 @default.
• W1489198622 crossrefType "journal-article" @default.
• W1489198622 hasAuthorship W1489198622A5062227791 @default.
• W1489198622 hasAuthorship W1489198622A5063449536 @default.
• W1489198622 hasAuthorship W1489198622A5089012338 @default.
• W1489198622 hasAuthorship W1489198622A5089661293 @default.
• W1489198622 hasBestOaLocation W14891986221 @default.
• W1489198622 hasConcept C11413529 @default.
• W1489198622 hasConcept C120665830 @default.
• W1489198622 hasConcept C121332964 @default.
• W1489198622 hasConcept C121608353 @default.
• W1489198622 hasConcept C126322002 @default.
• W1489198622 hasConcept C126838900 @default.
• W1489198622 hasConcept C126894567 @default.
• W1489198622 hasConcept C141071460 @default.
• W1489198622 hasConcept C146357865 @default.
• W1489198622 hasConcept C151730666 @default.
• W1489198622 hasConcept C2775934546 @default.
• W1489198622 hasConcept C2777546739 @default.
• W1489198622 hasConcept C2778660094 @default.
• W1489198622 hasConcept C2779466945 @default.
• W1489198622 hasConcept C2780192828 @default.
• W1489198622 hasConcept C2780824555 @default.
• W1489198622 hasConcept C2780849966 @default.
• W1489198622 hasConcept C41008148 @default.
• W1489198622 hasConcept C61511704 @default.
• W1489198622 hasConcept C71924100 @default.
• W1489198622 hasConcept C72563966 @default.
• W1489198622 hasConcept C86803240 @default.
• W1489198622 hasConceptScore W1489198622C11413529 @default.
• W1489198622 hasConceptScore W1489198622C120665830 @default.
• W1489198622 hasConceptScore W1489198622C121332964 @default.
• W1489198622 hasConceptScore W1489198622C121608353 @default.
• W1489198622 hasConceptScore W1489198622C126322002 @default.
• W1489198622 hasConceptScore W1489198622C126838900 @default.
• W1489198622 hasConceptScore W1489198622C126894567 @default.
• W1489198622 hasConceptScore W1489198622C141071460 @default.
• W1489198622 hasConceptScore W1489198622C146357865 @default.
• W1489198622 hasConceptScore W1489198622C151730666 @default.
• W1489198622 hasConceptScore W1489198622C2775934546 @default.
• W1489198622 hasConceptScore W1489198622C2777546739 @default.
• W1489198622 hasConceptScore W1489198622C2778660094 @default.
• W1489198622 hasConceptScore W1489198622C2779466945 @default.
• W1489198622 hasConceptScore W1489198622C2780192828 @default.
• W1489198622 hasConceptScore W1489198622C2780824555 @default.
• W1489198622 hasConceptScore W1489198622C2780849966 @default.
• W1489198622 hasConceptScore W1489198622C41008148 @default.
• W1489198622 hasConceptScore W1489198622C61511704 @default.
• W1489198622 hasConceptScore W1489198622C71924100 @default.
• W1489198622 hasConceptScore W1489198622C72563966 @default.
• W1489198622 hasConceptScore W1489198622C86803240 @default.
• W1489198622 hasIssue "5" @default.
• W1489198622 hasLocation W14891986221 @default.
• W1489198622 hasLocation W14891986222 @default.
• W1489198622 hasOpenAccess W1489198622 @default.
• W1489198622 hasPrimaryLocation W14891986221 @default.

• next