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- W1489201195 abstract "Alternative splicing of RNA transcripts has long been recognized as one way of generating molecular diversity. But a recent paper D. Schmucker et al., Cell 101, 1−20, 2000 sets what is surely a new record, with the identification of a Drosophila axon guidance receptor, termed Dscam, that has no fewer than 38,000 different isoforms. The extracellular domain is assembled in modular fashion, with multiple alternatives for each module (see diagram). Although it is possible that not all combinations are expressed in vivo, many clearly are: among 50 randomly selected Dscam cDNAs, 49 were unique." @default.
- W1489201195 created "2016-06-24" @default.
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- W1489201195 date "2000-07-01" @default.
- W1489201195 modified "2023-09-24" @default.
- W1489201195 title "A new high for alternative splicing" @default.
- W1489201195 doi "https://doi.org/10.1038/76590" @default.
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