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- W1489202523 abstract "To the Editor: Peters et al.1 reported that irbesartan showed no beneficial effects in hemodialysis patients by evaluating central aortic blood pressure and carotid-femoral pulse wave velocity. Their title was very impressive as previous studies proved the effects of an angiotensin receptor antagonist on hard end points in dialysis patients including our study.2 Originally, the purpose of central aortic blood pressure measurement was to detect the minute changes in vessels, which would not change the brachial blood pressure. Therefore, measurement of central aortic blood pressure might not be suitable for dialysis patients who show a high value because of aging and advanced arterial calcification. The pulse wave velocity of their patients was over 1100 cm/sec, although that of healthy men and women of the same generation was about 850 cm/sec in the Framingham Heart Study.3 Thus, it is supposed that an artery cannot respond to the effect of irbesartan on arterial stiffness, or central aortic blood pressure cannot detect the minute changes in arterial stiffness in dialysis patients. Laurent et al.4 reported that it took over 1 year of treatment to destiffen the arterial wall material even in younger hypertensive patients without renal diseases. Figuratively, one more underwear cannot change the body temperature or a thermometer cannot detect its minute changes in Antarctic blizzard. Treatment effects on the cardiovascular system in dialysis patients should be evaluated using hard end points." @default.
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- W1489202523 date "2015-07-01" @default.
- W1489202523 modified "2023-09-28" @default.
- W1489202523 title "Evaluating central blood pressure in dialysis patients" @default.
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- W1489202523 doi "https://doi.org/10.1038/ki.2015.90" @default.
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