FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489218093> ?p ?o ?g. }

• W1489218093 endingPage "225" @default.
• W1489218093 startingPage "207" @default.
• W1489218093 abstract "Entacapone and tolcapone are reversible COMT inhibitors which have been approved for clinical use in patients with Parkinson disease (PD). Nebicapone is a third COMT inhibitor which has been studied in humans. COMT inhibitors are used in combination with levodopa and a dopa decarboxylase (DDC) inhibitor. Each of them has problems either in pharmacokinetics, pharmacodynamics, clinical efficacy, or in safety. All three inhibitors have short elimination half-lives, about 2–3 h. Tolcapone is longer acting and more potent COMT inhibitor than entacapone; nebicapone lies in between. However, none of the present inhibitors cause a complete peripheral COMT inhibition. Tolcapone and nebicapone have increased more levodopa AUC than entacapone which is reflected also in their clinical efficacy. The most common adverse event with COMT inhibitors is dyskinesia which is usually managed by decreasing levodopa dose. The greatest problem with tolcapone and probably also with nebicapone is their liver toxicity which is not seen with entacapone. Tolcapone causes severe diarrhea more often than entacapone. Though the present COMT inhibitors have improved significantly the treatment of advanced PD patients, they still have several problems and weaknesses leaving room for developing better COMT inhibitors." @default.
• W1489218093 created "2016-06-24" @default.
• W1489218093 creator A5017864665 @default.
• W1489218093 date "2010-01-01" @default.
• W1489218093 modified "2023-10-17" @default.
• W1489218093 title "Problems with the Present Inhibitors and a Relevance of New and Improved COMT Inhibitors in Parkinson’s Disease" @default.
• W1489218093 cites W133817736 @default.
• W1489218093 cites W1489370470 @default.
• W1489218093 cites W1505745659 @default.
• W1489218093 cites W1714481020 @default.
• W1489218093 cites W1965128384 @default.
• W1489218093 cites W1965714500 @default.
• W1489218093 cites W1969372184 @default.
• W1489218093 cites W1973698406 @default.
• W1489218093 cites W1980384054 @default.
• W1489218093 cites W1982924711 @default.
• W1489218093 cites W1984616574 @default.
• W1489218093 cites W1991152368 @default.
• W1489218093 cites W1996330474 @default.
• W1489218093 cites W1996395058 @default.
• W1489218093 cites W2003612344 @default.
• W1489218093 cites W2004480672 @default.
• W1489218093 cites W2007202520 @default.
• W1489218093 cites W2008970808 @default.
• W1489218093 cites W2016013480 @default.
• W1489218093 cites W2016759354 @default.
• W1489218093 cites W2020613687 @default.
• W1489218093 cites W2020849440 @default.
• W1489218093 cites W2023765475 @default.
• W1489218093 cites W2031017582 @default.
• W1489218093 cites W2034266857 @default.
• W1489218093 cites W2034763673 @default.
• W1489218093 cites W2038996343 @default.
• W1489218093 cites W2048798939 @default.
• W1489218093 cites W2049993495 @default.
• W1489218093 cites W2051115769 @default.
• W1489218093 cites W2051557976 @default.
• W1489218093 cites W2052323065 @default.
• W1489218093 cites W2053402936 @default.
• W1489218093 cites W2054661622 @default.
• W1489218093 cites W2055958700 @default.
• W1489218093 cites W2058212676 @default.
• W1489218093 cites W2059417962 @default.
• W1489218093 cites W2060598809 @default.
• W1489218093 cites W2062036596 @default.
• W1489218093 cites W2062697517 @default.
• W1489218093 cites W2066270442 @default.
• W1489218093 cites W2066527639 @default.
• W1489218093 cites W2067722935 @default.
• W1489218093 cites W2069306719 @default.
• W1489218093 cites W2071991657 @default.
• W1489218093 cites W2078082626 @default.
• W1489218093 cites W2083033452 @default.
• W1489218093 cites W2084468949 @default.
• W1489218093 cites W2086360865 @default.
• W1489218093 cites W2090645860 @default.
• W1489218093 cites W2090991802 @default.
• W1489218093 cites W2092837440 @default.
• W1489218093 cites W2093200404 @default.
• W1489218093 cites W2094208951 @default.
• W1489218093 cites W2100984307 @default.
• W1489218093 cites W2112214600 @default.
• W1489218093 cites W2113689256 @default.
• W1489218093 cites W2123236884 @default.
• W1489218093 cites W2136406052 @default.
• W1489218093 cites W2144881416 @default.
• W1489218093 cites W2146977154 @default.
• W1489218093 cites W2149711671 @default.
• W1489218093 cites W2169424888 @default.
• W1489218093 cites W2400489782 @default.
• W1489218093 cites W2886390611 @default.
• W1489218093 cites W3022890122 @default.
• W1489218093 doi "https://doi.org/10.1016/b978-0-12-381326-8.00009-0" @default.
• W1489218093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21095464" @default.
• W1489218093 hasPublicationYear "2010" @default.
• W1489218093 type Work @default.
• W1489218093 sameAs 1489218093 @default.
• W1489218093 citedByCount "42" @default.
• W1489218093 countsByYear W14892180932012 @default.
• W1489218093 countsByYear W14892180932013 @default.
• W1489218093 countsByYear W14892180932014 @default.
• W1489218093 countsByYear W14892180932015 @default.
• W1489218093 countsByYear W14892180932016 @default.
• W1489218093 countsByYear W14892180932017 @default.
• W1489218093 countsByYear W14892180932018 @default.
• W1489218093 countsByYear W14892180932019 @default.
• W1489218093 countsByYear W14892180932020 @default.
• W1489218093 countsByYear W14892180932021 @default.
• W1489218093 countsByYear W14892180932022 @default.
• W1489218093 countsByYear W14892180932023 @default.
• W1489218093 crossrefType "book-chapter" @default.
• W1489218093 hasAuthorship W1489218093A5017864665 @default.
• W1489218093 hasConcept C104317684 @default.
• W1489218093 hasConcept C111113717 @default.
• W1489218093 hasConcept C112705442 @default.
• W1489218093 hasConcept C126322002 @default.
• W1489218093 hasConcept C135763542 @default.
• W1489218093 hasConcept C185361966 @default.

• next