FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489222002> ?p ?o ?g. }

• W1489222002 endingPage "182" @default.
• W1489222002 startingPage "172" @default.
• W1489222002 abstract "The search for the missing heritability in genome-wide association studies (GWAS) has become an important focus for the human genetics community. One suspected location of these genetic effects is in gene-gene interactions, or epistasis. The computational burden of exploring gene-gene interactions in the wealth of data generated in GWAS, along with small to moderate sample sizes, have led to epistasis being an afterthought, rather than a primary focus of GWAS analyses. In this review, I discuss some potential approaches to filter a GWAS dataset to a smaller, more manageable dataset where searching for epistasis is considerably more feasible. I describe a number of alternative approaches, but primarily focus on the use of prior biological knowledge from databases in the public domain to guide the search for epistasis. The manner in which prior knowledge is incorporated into a GWA study can be many and these data can be extracted from a variety of database sources. I discuss a number of these approaches and propose that a comprehensive approach will likely be most fruitful for searching for epistasis in large-scale genomic studies of the current state-of-the-art and into the future." @default.
• W1489222002 created "2016-06-24" @default.
• W1489222002 creator A5081769614 @default.
• W1489222002 date "2010-12-15" @default.
• W1489222002 modified "2023-10-14" @default.
• W1489222002 title "Using Biological Knowledge to Uncover the Mystery in the Search for Epistasis in Genome-Wide Association Studies" @default.
• W1489222002 cites W1480376833 @default.
• W1489222002 cites W1493454437 @default.
• W1489222002 cites W1515176900 @default.
• W1489222002 cites W180744188 @default.
• W1489222002 cites W1964263547 @default.
• W1489222002 cites W1965536350 @default.
• W1489222002 cites W1966157852 @default.
• W1489222002 cites W1966315117 @default.
• W1489222002 cites W1966360257 @default.
• W1489222002 cites W1978191412 @default.
• W1489222002 cites W1978926020 @default.
• W1489222002 cites W1981723690 @default.
• W1489222002 cites W1981970248 @default.
• W1489222002 cites W1982839620 @default.
• W1489222002 cites W1986604923 @default.
• W1489222002 cites W1991160835 @default.
• W1489222002 cites W1996824414 @default.
• W1489222002 cites W1998003466 @default.
• W1489222002 cites W2007669896 @default.
• W1489222002 cites W2012280706 @default.
• W1489222002 cites W2014780134 @default.
• W1489222002 cites W2019983262 @default.
• W1489222002 cites W2024860192 @default.
• W1489222002 cites W2025594403 @default.
• W1489222002 cites W2031873733 @default.
• W1489222002 cites W2033383209 @default.
• W1489222002 cites W2033502535 @default.
• W1489222002 cites W2040709122 @default.
• W1489222002 cites W2043192290 @default.
• W1489222002 cites W2044164200 @default.
• W1489222002 cites W2049963771 @default.
• W1489222002 cites W2051616601 @default.
• W1489222002 cites W2051669955 @default.
• W1489222002 cites W2058148991 @default.
• W1489222002 cites W2064539914 @default.
• W1489222002 cites W2065121811 @default.
• W1489222002 cites W2067523962 @default.
• W1489222002 cites W2070082005 @default.
• W1489222002 cites W2070412833 @default.
• W1489222002 cites W2072664252 @default.
• W1489222002 cites W2073881372 @default.
• W1489222002 cites W2074199852 @default.
• W1489222002 cites W2078477574 @default.
• W1489222002 cites W2080030928 @default.
• W1489222002 cites W2083944388 @default.
• W1489222002 cites W2084974619 @default.
• W1489222002 cites W2085779097 @default.
• W1489222002 cites W2086753644 @default.
• W1489222002 cites W2090713084 @default.
• W1489222002 cites W2093669238 @default.
• W1489222002 cites W2094183969 @default.
• W1489222002 cites W2097099463 @default.
• W1489222002 cites W2100941248 @default.
• W1489222002 cites W2104486572 @default.
• W1489222002 cites W2104605543 @default.
• W1489222002 cites W2105110560 @default.
• W1489222002 cites W2106508416 @default.
• W1489222002 cites W2114740540 @default.
• W1489222002 cites W2116910732 @default.
• W1489222002 cites W2117446594 @default.
• W1489222002 cites W2117812871 @default.
• W1489222002 cites W2121250859 @default.
• W1489222002 cites W2122250592 @default.
• W1489222002 cites W2127405401 @default.
• W1489222002 cites W2130687290 @default.
• W1489222002 cites W2131878646 @default.
• W1489222002 cites W2139647754 @default.
• W1489222002 cites W2141653244 @default.
• W1489222002 cites W2143967211 @default.
• W1489222002 cites W2148967786 @default.
• W1489222002 cites W2151499551 @default.
• W1489222002 cites W2154572047 @default.
• W1489222002 cites W2162237466 @default.
• W1489222002 cites W2167638767 @default.
• W1489222002 cites W2168391930 @default.
• W1489222002 cites W2168614691 @default.
• W1489222002 cites W2170133641 @default.
• W1489222002 cites W2303043072 @default.
• W1489222002 cites W2407942904 @default.
• W1489222002 cites W2916288174 @default.
• W1489222002 cites W2917431650 @default.
• W1489222002 cites W4205232216 @default.
• W1489222002 doi "https://doi.org/10.1111/j.1469-1809.2010.00630.x" @default.
• W1489222002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3092784" @default.
• W1489222002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21158748" @default.
• W1489222002 hasPublicationYear "2010" @default.
• W1489222002 type Work @default.
• W1489222002 sameAs 1489222002 @default.
• W1489222002 citedByCount "73" @default.
• W1489222002 countsByYear W14892220022012 @default.
• W1489222002 countsByYear W14892220022013 @default.
• W1489222002 countsByYear W14892220022014 @default.

• next