FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489291293> ?p ?o ?g. }

• W1489291293 endingPage "684" @default.
• W1489291293 startingPage "676" @default.
• W1489291293 abstract "Aim: Our previous “J-BENEFIT (Japan BEzafibrate cliNical EFfectIveness and Tolerability)” study demonstrated that bezafibrate improves blood lipid profiles and glucose control in dyslipidemic patients with diabetes. However, bezafibrate did not significantly improve low-density lipoprotein cholesterol (LDL-C), although some patients showed decreases while others showed increases in the LDL-C levels. Therefore, a subgroup analysis of the J-BENEFIT study was conducted to identify factors influencing the bezafibrate-induced changes in the LDL-C levels.Methods: Of the 3,316 patients in the J-BENEFIT study, 2,116 not treated with other lipid-lowering drugs were enrolled in the current study, and the effects of 24-week treatment with bezafibrate on the LDL-C levels were analyzed. A reduction in the LDL-C level of ≥ 25% occurred in 253 patients, and a logistic-regression analysis was used to identify factors associated with this improvement.Results: Among the 2,116 overall patients, bezafibrate treatment significantly increased the LDL-C levels from 123.9±36.7 to 125.7±31.3 mg/dL. The subanalysis showed that the treatment responses varied according to the baseline LDL-C level, with significant decreases in the ≥ 160 and ≥ 140-＜160 mg/dL groups, no significant decrease in the ≥ 120-＜140 mg/dL group and a significant increase in the ＜120 mg/dL group. A multivariate logistic-regression analysis of the data for the patients with an LDL-C of ≥ 25% identified a female sex, the use of anti-hypertensive and hypoglycemic agents and a high baseline LDL-C level to be significant determinants of the LDL-C response to bezafibrate.Conclusions: Our results showed that treatment with bezafibrate improves the LDL-C levels and lipid profiles in dyslipidemic diabetic patients, especially women, subjects co-treated with anti-hypertensive or hypoglycemic agents and those with high baseline LDL-C levels." @default.
• W1489291293 created "2016-06-24" @default.
• W1489291293 creator A5031900155 @default.
• W1489291293 creator A5049677961 @default.
• W1489291293 creator A5056284035 @default.
• W1489291293 creator A5086170090 @default.
• W1489291293 date "2015-01-01" @default.
• W1489291293 modified "2023-10-16" @default.
• W1489291293 title "Determinants of Bezafibrate-induced Improvements in LDL Cholesterol in Dyslipidemic Patients with Diabetes" @default.
• W1489291293 cites W120848922 @default.
• W1489291293 cites W1965344989 @default.
• W1489291293 cites W1977868067 @default.
• W1489291293 cites W1982444046 @default.
• W1489291293 cites W1982780082 @default.
• W1489291293 cites W1990421153 @default.
• W1489291293 cites W1991436488 @default.
• W1489291293 cites W2023590870 @default.
• W1489291293 cites W2027059652 @default.
• W1489291293 cites W2053266260 @default.
• W1489291293 cites W2071214196 @default.
• W1489291293 cites W2071891597 @default.
• W1489291293 cites W2074212819 @default.
• W1489291293 cites W2084676615 @default.
• W1489291293 cites W2089103283 @default.
• W1489291293 cites W2092761225 @default.
• W1489291293 cites W2097785866 @default.
• W1489291293 cites W2097870088 @default.
• W1489291293 cites W2097875878 @default.
• W1489291293 cites W2101231181 @default.
• W1489291293 cites W2113016530 @default.
• W1489291293 cites W2114328886 @default.
• W1489291293 cites W2114819765 @default.
• W1489291293 cites W2116404316 @default.
• W1489291293 cites W2120655733 @default.
• W1489291293 cites W2130581440 @default.
• W1489291293 cites W2156597891 @default.
• W1489291293 cites W2162136177 @default.
• W1489291293 cites W2164089346 @default.
• W1489291293 cites W2164247714 @default.
• W1489291293 cites W2247997571 @default.
• W1489291293 doi "https://doi.org/10.5551/jat.27425" @default.
• W1489291293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25752494" @default.
• W1489291293 hasPublicationYear "2015" @default.
• W1489291293 type Work @default.
• W1489291293 sameAs 1489291293 @default.
• W1489291293 citedByCount "11" @default.
• W1489291293 countsByYear W14892912932015 @default.
• W1489291293 countsByYear W14892912932017 @default.
• W1489291293 countsByYear W14892912932018 @default.
• W1489291293 countsByYear W14892912932021 @default.
• W1489291293 countsByYear W14892912932022 @default.
• W1489291293 crossrefType "journal-article" @default.
• W1489291293 hasAuthorship W1489291293A5031900155 @default.
• W1489291293 hasAuthorship W1489291293A5049677961 @default.
• W1489291293 hasAuthorship W1489291293A5056284035 @default.
• W1489291293 hasAuthorship W1489291293A5086170090 @default.
• W1489291293 hasBestOaLocation W14892912931 @default.
• W1489291293 hasConcept C126322002 @default.
• W1489291293 hasConcept C134018914 @default.
• W1489291293 hasConcept C151956035 @default.
• W1489291293 hasConcept C197934379 @default.
• W1489291293 hasConcept C2776362216 @default.
• W1489291293 hasConcept C2778096610 @default.
• W1489291293 hasConcept C2778163477 @default.
• W1489291293 hasConcept C2778375690 @default.
• W1489291293 hasConcept C3019550498 @default.
• W1489291293 hasConcept C555293320 @default.
• W1489291293 hasConcept C71924100 @default.
• W1489291293 hasConcept C90924648 @default.
• W1489291293 hasConceptScore W1489291293C126322002 @default.
• W1489291293 hasConceptScore W1489291293C134018914 @default.
• W1489291293 hasConceptScore W1489291293C151956035 @default.
• W1489291293 hasConceptScore W1489291293C197934379 @default.
• W1489291293 hasConceptScore W1489291293C2776362216 @default.
• W1489291293 hasConceptScore W1489291293C2778096610 @default.
• W1489291293 hasConceptScore W1489291293C2778163477 @default.
• W1489291293 hasConceptScore W1489291293C2778375690 @default.
• W1489291293 hasConceptScore W1489291293C3019550498 @default.
• W1489291293 hasConceptScore W1489291293C555293320 @default.
• W1489291293 hasConceptScore W1489291293C71924100 @default.
• W1489291293 hasConceptScore W1489291293C90924648 @default.
• W1489291293 hasIssue "7" @default.
• W1489291293 hasLocation W14892912931 @default.
• W1489291293 hasLocation W14892912932 @default.
• W1489291293 hasOpenAccess W1489291293 @default.
• W1489291293 hasPrimaryLocation W14892912931 @default.
• W1489291293 hasRelatedWork W1972011552 @default.
• W1489291293 hasRelatedWork W1991283631 @default.
• W1489291293 hasRelatedWork W2005998106 @default.
• W1489291293 hasRelatedWork W2023154173 @default.
• W1489291293 hasRelatedWork W2028009073 @default.
• W1489291293 hasRelatedWork W2032958076 @default.
• W1489291293 hasRelatedWork W2059941456 @default.
• W1489291293 hasRelatedWork W2127396703 @default.
• W1489291293 hasRelatedWork W2128639389 @default.
• W1489291293 hasRelatedWork W11197745 @default.
• W1489291293 hasVolume "22" @default.
• W1489291293 isParatext "false" @default.

• next