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- W1489294105 abstract "This chapter provides an overview on molecular strategies for prevention of sexually transmitted viral disease. The chapter focuses on the perceived need, basic research challenges, and scientific grounds for confidence in the development of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) microbicides with emphasis on viral/pathogen synergies and mucosal factors of susceptibility. Synergistic mechanisms underlying the phenomenon of amplified transmission are discussed in the chapter. Mathematical modeling predicts that even a partial protection would substantially relieve the burden of the HIV pandemic. Nevertheless, because of the viral diversity and the complexity and redundancy of the viral mucosal penetration routes, it is unlikely that a single microbicide or multiple microbicides inhibiting acquisition via a single target would prove to be fully efficient. The major mechanisms of action targeted by microbicides, so far, are degrading or neutralizing the virus before it reaches its target cells, blocking the viral entry and intercellular passage, as well as attacking the intra-cellular steps of the viral cycle, mainly the reverse transcription and viral integration processes. The mechanism of action of the antiretroviral drugs nucleoside and non-nucleoside RT inhibitors (NRTIs and NNRTIs) is discussed in detail. The development of prevention strategies and tools to encompass the global diversity of HIV-1, to be holistically compatible with the wide range of age and multicultural and socioeconomic backgrounds, is a colossal international undertaking that has mobilized scientists, advocates, philanthropists, and policy makers around the world." @default.
- W1489294105 created "2016-06-24" @default.
- W1489294105 creator A5043044043 @default.
- W1489294105 date "2014-04-30" @default.
- W1489294105 modified "2023-09-27" @default.
- W1489294105 title "Microbicides: Molecular Strategies for Prevention of Sexually Transmitted Viral Disease" @default.
- W1489294105 cites W1489648949 @default.
- W1489294105 cites W1525927184 @default.
- W1489294105 cites W1699035887 @default.
- W1489294105 cites W1754420817 @default.
- W1489294105 cites W1866854460 @default.
- W1489294105 cites W1892302877 @default.
- W1489294105 cites W1963616625 @default.
- W1489294105 cites W1964117483 @default.
- W1489294105 cites W1968013693 @default.
- W1489294105 cites W1974054879 @default.
- W1489294105 cites W1978230446 @default.
- W1489294105 cites W1983104992 @default.
- W1489294105 cites W1983183505 @default.
- W1489294105 cites W1984105046 @default.
- W1489294105 cites W1988706339 @default.
- W1489294105 cites W1989829210 @default.
- W1489294105 cites W1992677585 @default.
- W1489294105 cites W1994842809 @default.
- W1489294105 cites W1995710614 @default.
- W1489294105 cites W1997351179 @default.
- W1489294105 cites W1999097619 @default.
- W1489294105 cites W2000245109 @default.
- W1489294105 cites W2001280184 @default.
- W1489294105 cites W2004258189 @default.
- W1489294105 cites W2005570240 @default.
- W1489294105 cites W2005779622 @default.
- W1489294105 cites W2017841667 @default.
- W1489294105 cites W2019120007 @default.
- W1489294105 cites W2019632798 @default.
- W1489294105 cites W2020078789 @default.
- W1489294105 cites W2026833879 @default.
- W1489294105 cites W2028100045 @default.
- W1489294105 cites W2028144465 @default.
- W1489294105 cites W2029455707 @default.
- W1489294105 cites W2031495220 @default.
- W1489294105 cites W2032186556 @default.
- W1489294105 cites W2036151418 @default.
- W1489294105 cites W2038010722 @default.
- W1489294105 cites W2038075095 @default.
- W1489294105 cites W2039899944 @default.
- W1489294105 cites W2040576304 @default.
- W1489294105 cites W2041095686 @default.
- W1489294105 cites W2043007961 @default.
- W1489294105 cites W2043423849 @default.
- W1489294105 cites W2051464900 @default.
- W1489294105 cites W2051946274 @default.
- W1489294105 cites W2055551548 @default.
- W1489294105 cites W2056155481 @default.
- W1489294105 cites W2056871273 @default.
- W1489294105 cites W2058243481 @default.
- W1489294105 cites W2060534608 @default.
- W1489294105 cites W2060622767 @default.
- W1489294105 cites W2062006468 @default.
- W1489294105 cites W2063396671 @default.
- W1489294105 cites W2064397003 @default.
- W1489294105 cites W2069813795 @default.
- W1489294105 cites W2070201206 @default.
- W1489294105 cites W2071188435 @default.
- W1489294105 cites W2072777974 @default.
- W1489294105 cites W2074673603 @default.
- W1489294105 cites W2074918485 @default.
- W1489294105 cites W2075201634 @default.
- W1489294105 cites W2076799931 @default.
- W1489294105 cites W2078206584 @default.
- W1489294105 cites W2080499742 @default.
- W1489294105 cites W2086298451 @default.
- W1489294105 cites W2086992545 @default.
- W1489294105 cites W2087219615 @default.
- W1489294105 cites W2088747167 @default.
- W1489294105 cites W2092525157 @default.
- W1489294105 cites W2095553811 @default.
- W1489294105 cites W2097903159 @default.
- W1489294105 cites W2098407949 @default.
- W1489294105 cites W2100702091 @default.
- W1489294105 cites W2106853491 @default.
- W1489294105 cites W2108120404 @default.
- W1489294105 cites W2108622456 @default.
- W1489294105 cites W2111621727 @default.
- W1489294105 cites W2112631257 @default.
- W1489294105 cites W2115059789 @default.
- W1489294105 cites W2116590547 @default.
- W1489294105 cites W2116610565 @default.
- W1489294105 cites W2117705817 @default.
- W1489294105 cites W2119524073 @default.
- W1489294105 cites W2120078856 @default.
- W1489294105 cites W2120943472 @default.
- W1489294105 cites W2121296127 @default.
- W1489294105 cites W2128556228 @default.
- W1489294105 cites W2128648447 @default.
- W1489294105 cites W2129431697 @default.
- W1489294105 cites W2130167865 @default.
- W1489294105 cites W2130703653 @default.