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- W1489336240 abstract "Humans and great apes (collectively known as the hominoids) share genomes of very similar size. Humans and chimpanzees shared a common ancestor 5–6 million years ago. Changes in regulatory regions affecting gene expression have been postulated, and a study has shown that gene expression differs especially in the brain. Furthermore, there is evidence of uniquely human segmental duplications accumulating near chromosome centromeres. Some of these harbor differences in transcripts between great apes and humans. Very few genomic differences that cause major changes in coding sequences of unique genes are documented, but at least one leads to a widespread biochemical difference. Humans and great apes share remarkably similar genomes.There is evidence for long predicted changes in gene regulation,and we are beginning to learn about small genetic differences with large phenotypic consequences.Keywords:hominoid;great apes;human evolution;comparative genomics" @default.
- W1489336240 created "2016-06-24" @default.
- W1489336240 creator A5069452689 @default.
- W1489336240 date "2006-09-15" @default.
- W1489336240 modified "2023-09-25" @default.
- W1489336240 title "Great Apes and Humans: Genetic Differences" @default.
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- W1489336240 doi "https://doi.org/10.1002/9780470015902.a0006115" @default.
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