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- W1489361097 abstract "The rate of relaxation of supercoiled DNA by purified vaccinia topoisomerase I is stimulated 20-fold by 5 mM ATP. A similar effect is elicited by GTP, CTP, UTP, dATP, and adenosine 5'-(beta, gamma-imido)triphosphate. ATP-mediated rate enhancement requires salt as a coactivator. ADP and inorganic pyrophosphate also stimulate relaxation 10-20-fold, whereas AMP and inorganic phosphate have little effect. A model for allosteric activation of topoisomerase by nucleotides is suggested." @default.
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- W1489361097 date "1994-11-01" @default.
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- W1489361097 title "Stimulation of vaccinia topoisomerase I by nucleoside triphosphates." @default.
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- W1489361097 doi "https://doi.org/10.1016/s0021-9258(18)43946-4" @default.
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