Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489363586> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1489363586 endingPage "375" @default.
- W1489363586 startingPage "367" @default.
- W1489363586 abstract "We describe a new experimental approach designed to detect signals transduced to B cells that have interacted, in an antigen-mediated mechanism, with helper T cells that cannot release soluble mediators. For this purpose, cells from an antigen-specific T helper cell line were treated with cyclosporin A (CSA). The stimulation of CSA-treated T cells with specific antigen in the presence of low concentrations of CSA, demonstrated that the T cells did not release detectable levels of interleukin-2, interleukin-4, and interleukin-5. When such CSA-treated T cells interacted with hapten-specific B cells in the presence of specific antigen, the B cells were found to develop responsiveness to exogenously added growth and differentiation inducing soluble mediators. The development of lymphokine responsiveness in such cultures could be partially blocked by the addition of a monoclonal antibody specific for major histocompatibility complex class II molecules expressed on the B cell surfaces. These results indicated that antigen-mediated interaction between B and T cells, in the absence of lymphokines, resulted in a phenotypic change in B cell behavior and suggested that the signal that promoted this change occurred as a consequence of the T cell antigen receptor binding to B cell surface Ia in association with processed antigen. This experimental system should afford an opportunity to determine the biochemical and molecular consequences in B cells that have interacted, by direct cell contact, with helper T cells." @default.
- W1489363586 created "2016-06-24" @default.
- W1489363586 creator A5028026798 @default.
- W1489363586 creator A5078559694 @default.
- W1489363586 date "1988-01-15" @default.
- W1489363586 modified "2023-10-16" @default.
- W1489363586 title "Induction of lymphokine responsiveness of hapten-specific B lymphocytes promoted through an antigen-mediated T helper lymphocyte interaction." @default.
- W1489363586 doi "https://doi.org/10.4049/jimmunol.140.2.367" @default.
- W1489363586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2447174" @default.
- W1489363586 hasPublicationYear "1988" @default.
- W1489363586 type Work @default.
- W1489363586 sameAs 1489363586 @default.
- W1489363586 citedByCount "33" @default.
- W1489363586 crossrefType "journal-article" @default.
- W1489363586 hasAuthorship W1489363586A5028026798 @default.
- W1489363586 hasAuthorship W1489363586A5078559694 @default.
- W1489363586 hasConcept C147483822 @default.
- W1489363586 hasConcept C153911025 @default.
- W1489363586 hasConcept C159654299 @default.
- W1489363586 hasConcept C203014093 @default.
- W1489363586 hasConcept C207936829 @default.
- W1489363586 hasConcept C2776090121 @default.
- W1489363586 hasConcept C2777371288 @default.
- W1489363586 hasConcept C2778453870 @default.
- W1489363586 hasConcept C2781136212 @default.
- W1489363586 hasConcept C2992881475 @default.
- W1489363586 hasConcept C49382859 @default.
- W1489363586 hasConcept C67662055 @default.
- W1489363586 hasConcept C86803240 @default.
- W1489363586 hasConcept C8891405 @default.
- W1489363586 hasConcept C95444343 @default.
- W1489363586 hasConceptScore W1489363586C147483822 @default.
- W1489363586 hasConceptScore W1489363586C153911025 @default.
- W1489363586 hasConceptScore W1489363586C159654299 @default.
- W1489363586 hasConceptScore W1489363586C203014093 @default.
- W1489363586 hasConceptScore W1489363586C207936829 @default.
- W1489363586 hasConceptScore W1489363586C2776090121 @default.
- W1489363586 hasConceptScore W1489363586C2777371288 @default.
- W1489363586 hasConceptScore W1489363586C2778453870 @default.
- W1489363586 hasConceptScore W1489363586C2781136212 @default.
- W1489363586 hasConceptScore W1489363586C2992881475 @default.
- W1489363586 hasConceptScore W1489363586C49382859 @default.
- W1489363586 hasConceptScore W1489363586C67662055 @default.
- W1489363586 hasConceptScore W1489363586C86803240 @default.
- W1489363586 hasConceptScore W1489363586C8891405 @default.
- W1489363586 hasConceptScore W1489363586C95444343 @default.
- W1489363586 hasIssue "2" @default.
- W1489363586 hasLocation W14893635861 @default.
- W1489363586 hasLocation W14893635862 @default.
- W1489363586 hasOpenAccess W1489363586 @default.
- W1489363586 hasPrimaryLocation W14893635861 @default.
- W1489363586 hasRelatedWork W1489363586 @default.
- W1489363586 hasRelatedWork W1586369900 @default.
- W1489363586 hasRelatedWork W1973428630 @default.
- W1489363586 hasRelatedWork W1991683291 @default.
- W1489363586 hasRelatedWork W2000941383 @default.
- W1489363586 hasRelatedWork W2055727922 @default.
- W1489363586 hasRelatedWork W2108857524 @default.
- W1489363586 hasRelatedWork W2147663822 @default.
- W1489363586 hasRelatedWork W2410833002 @default.
- W1489363586 hasRelatedWork W92278873 @default.
- W1489363586 hasVolume "140" @default.
- W1489363586 isParatext "false" @default.
- W1489363586 isRetracted "false" @default.
- W1489363586 magId "1489363586" @default.
- W1489363586 workType "article" @default.