Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489383809> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1489383809 endingPage "169" @default.
- W1489383809 startingPage "166" @default.
- W1489383809 abstract "Objective: The main objective of present work is to synthesize, characterize and evaluate DNA photocleavage activity of hydrazones containing quinoline and pyrimidine rings. Methods: The syntheses of new 2-(Thioxo/Oxo)quinoline-4,6-dimethyl pyrimidinyl hydrazones has been achieved by the reaction of 2-(Thioxo/Oxo)quinoline-3-carbaldehydes and 2-hydrazino-4, 6-dimethylpyrimidine. The structure of synthesized compounds is established on basis of data obtained from the spectroscopic techniques such as 1 H NMR, 13 C NMR, FT-IR and mass. The synthesized compounds were evaluated for their DNA photocleavage activity at 40 μg/μl concentration by agarose gel electrophoresis method. Results: The synthesized compounds 5e showed complete cleavage of DNA while 5a , 5b and 6e showed significant cleavage potential. Conclusion: A series of novel hydrazones bearing quinoline and pyrimidine moiety has been synthesized and well characterized on the basis of spectroscopic data and further evaluated for their DNA photocleavage activity. It has been observed that compounds having bromo and thio group displayed good activity." @default.
- W1489383809 created "2016-06-24" @default.
- W1489383809 creator A5002999742 @default.
- W1489383809 creator A5013016297 @default.
- W1489383809 creator A5019470605 @default.
- W1489383809 creator A5034120061 @default.
- W1489383809 date "2014-09-01" @default.
- W1489383809 modified "2023-09-27" @default.
- W1489383809 title "SYNTHESIS, CHARACTERISATION AND DNA PHOTOCLEAVAGE ACTIVITY OF NEW 2-(THIOXO/OXO) QUINOLINE-4,6-DIMETHYL PYRIMIDINYL HYDRAZONES" @default.
- W1489383809 cites W178253875 @default.
- W1489383809 cites W1971389772 @default.
- W1489383809 cites W1980085039 @default.
- W1489383809 cites W1982769640 @default.
- W1489383809 cites W1993160816 @default.
- W1489383809 cites W2007718707 @default.
- W1489383809 cites W2009978158 @default.
- W1489383809 cites W2010583103 @default.
- W1489383809 cites W2039592259 @default.
- W1489383809 cites W2048868829 @default.
- W1489383809 cites W2069764649 @default.
- W1489383809 cites W2074068135 @default.
- W1489383809 cites W2085698379 @default.
- W1489383809 cites W2094943549 @default.
- W1489383809 cites W2099980263 @default.
- W1489383809 cites W2115187133 @default.
- W1489383809 cites W2149023301 @default.
- W1489383809 cites W2174705034 @default.
- W1489383809 cites W2189047689 @default.
- W1489383809 cites W2282186866 @default.
- W1489383809 cites W2582443885 @default.
- W1489383809 cites W2949383545 @default.
- W1489383809 cites W2949750594 @default.
- W1489383809 cites W2182122541 @default.
- W1489383809 cites W2488965338 @default.
- W1489383809 hasPublicationYear "2014" @default.
- W1489383809 type Work @default.
- W1489383809 sameAs 1489383809 @default.
- W1489383809 citedByCount "0" @default.
- W1489383809 crossrefType "journal-article" @default.
- W1489383809 hasAuthorship W1489383809A5002999742 @default.
- W1489383809 hasAuthorship W1489383809A5013016297 @default.
- W1489383809 hasAuthorship W1489383809A5019470605 @default.
- W1489383809 hasAuthorship W1489383809A5034120061 @default.
- W1489383809 hasConcept C103319777 @default.
- W1489383809 hasConcept C155647269 @default.
- W1489383809 hasConcept C159985019 @default.
- W1489383809 hasConcept C175156509 @default.
- W1489383809 hasConcept C178790620 @default.
- W1489383809 hasConcept C185592680 @default.
- W1489383809 hasConcept C192562407 @default.
- W1489383809 hasConcept C21951064 @default.
- W1489383809 hasConcept C2776309666 @default.
- W1489383809 hasConcept C2776568683 @default.
- W1489383809 hasConcept C2778271344 @default.
- W1489383809 hasConcept C2779321679 @default.
- W1489383809 hasConcept C2781253882 @default.
- W1489383809 hasConcept C43369102 @default.
- W1489383809 hasConcept C552990157 @default.
- W1489383809 hasConcept C55493867 @default.
- W1489383809 hasConcept C71240020 @default.
- W1489383809 hasConceptScore W1489383809C103319777 @default.
- W1489383809 hasConceptScore W1489383809C155647269 @default.
- W1489383809 hasConceptScore W1489383809C159985019 @default.
- W1489383809 hasConceptScore W1489383809C175156509 @default.
- W1489383809 hasConceptScore W1489383809C178790620 @default.
- W1489383809 hasConceptScore W1489383809C185592680 @default.
- W1489383809 hasConceptScore W1489383809C192562407 @default.
- W1489383809 hasConceptScore W1489383809C21951064 @default.
- W1489383809 hasConceptScore W1489383809C2776309666 @default.
- W1489383809 hasConceptScore W1489383809C2776568683 @default.
- W1489383809 hasConceptScore W1489383809C2778271344 @default.
- W1489383809 hasConceptScore W1489383809C2779321679 @default.
- W1489383809 hasConceptScore W1489383809C2781253882 @default.
- W1489383809 hasConceptScore W1489383809C43369102 @default.
- W1489383809 hasConceptScore W1489383809C552990157 @default.
- W1489383809 hasConceptScore W1489383809C55493867 @default.
- W1489383809 hasConceptScore W1489383809C71240020 @default.
- W1489383809 hasIssue "9" @default.
- W1489383809 hasLocation W14893838091 @default.
- W1489383809 hasOpenAccess W1489383809 @default.
- W1489383809 hasPrimaryLocation W14893838091 @default.
- W1489383809 hasVolume "6" @default.
- W1489383809 isParatext "false" @default.
- W1489383809 isRetracted "false" @default.
- W1489383809 magId "1489383809" @default.
- W1489383809 workType "article" @default.