FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489389999> ?p ?o ?g. }

• W1489389999 endingPage "1993" @default.
• W1489389999 startingPage "1988" @default.
• W1489389999 abstract "Abstract Fas ligand (FasL) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells. We have reported that NK cell functions, such as proliferation, cell death, and killing activity, are subject to regulation by cellular redox status. Here, we report that expression of FasL protein and mRNA in activated NK cells is also regulated by redox. Ligation of CD16 on IL-2-preactivated NK cells resulted in reduction of intracellular peroxide level as well as induction of FasL expression. This CD16-induced FasL expression was suppressed by oxidative stress, including thiol deprivation or treatment with hydrogen peroxide (H2O2). Addition of thiol-reducing compounds, such as l-cystine, 2-ME, or N-acetyl cysteine, restored FasL expression. These data suggest that CD16 stimulation requires cellular reducing status for FasL induction in NK cells. Because FasL gene activation following CD16 cross-linking is regulated by the NF of activated T cells (NFAT), we examined the effect of oxidative stresses on NFAT activation. Electrophoretic mobility shift assays revealed that both thiol insufficiency and H2O2 treatment suppressed DNA-binding activity of NFAT and that addition of thiol-reducing compounds reversed or even enhanced it. Furthermore, these oxidative stresses inhibited activity of calcineurin, a serine/threonine phosphatase that regulates NFAT activation. These results suggest that suppression of calcineurin and NFAT activation is a mechanism by which oxidative stress inhibits FasL induction in activated NK cells and further support the hypothesis that thiol-reducing compounds might be required for maintenance of optimal NK functions under physiologic oxidative conditions." @default.
• W1489389999 created "2016-06-24" @default.
• W1489389999 creator A5035904647 @default.
• W1489389999 creator A5063483109 @default.
• W1489389999 creator A5076741471 @default.
• W1489389999 creator A5091383746 @default.
• W1489389999 date "1999-02-15" @default.
• W1489389999 modified "2023-10-16" @default.
• W1489389999 title "Fas Ligand Induction in Human NK Cells Is Regulated by Redox Through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway" @default.
• W1489389999 cites W1481489069 @default.
• W1489389999 cites W1483711789 @default.
• W1489389999 cites W1501442799 @default.
• W1489389999 cites W1568529372 @default.
• W1489389999 cites W1581932048 @default.
• W1489389999 cites W1639627597 @default.
• W1489389999 cites W1734082729 @default.
• W1489389999 cites W1819230692 @default.
• W1489389999 cites W1912361619 @default.
• W1489389999 cites W1932520996 @default.
• W1489389999 cites W1937597488 @default.
• W1489389999 cites W1969971113 @default.
• W1489389999 cites W1975107946 @default.
• W1489389999 cites W1979971695 @default.
• W1489389999 cites W1999642772 @default.
• W1489389999 cites W1999764514 @default.
• W1489389999 cites W2001246952 @default.
• W1489389999 cites W2002733542 @default.
• W1489389999 cites W2004645606 @default.
• W1489389999 cites W2004720912 @default.
• W1489389999 cites W2009588836 @default.
• W1489389999 cites W2016730049 @default.
• W1489389999 cites W2018365938 @default.
• W1489389999 cites W2041466047 @default.
• W1489389999 cites W2051376175 @default.
• W1489389999 cites W2068001141 @default.
• W1489389999 cites W2069808501 @default.
• W1489389999 cites W2070693959 @default.
• W1489389999 cites W2073746671 @default.
• W1489389999 cites W2074593407 @default.
• W1489389999 cites W2086313080 @default.
• W1489389999 cites W2090763028 @default.
• W1489389999 cites W2097131805 @default.
• W1489389999 cites W2102250325 @default.
• W1489389999 cites W2112278496 @default.
• W1489389999 cites W2127065677 @default.
• W1489389999 cites W2159747058 @default.
• W1489389999 cites W2164802863 @default.
• W1489389999 cites W2166225209 @default.
• W1489389999 cites W4249208404 @default.
• W1489389999 cites W4313333645 @default.
• W1489389999 cites W72542159 @default.
• W1489389999 doi "https://doi.org/10.4049/jimmunol.162.4.1988" @default.
• W1489389999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9973469" @default.
• W1489389999 hasPublicationYear "1999" @default.
• W1489389999 type Work @default.
• W1489389999 sameAs 1489389999 @default.
• W1489389999 citedByCount "70" @default.
• W1489389999 countsByYear W14893899992012 @default.
• W1489389999 countsByYear W14893899992013 @default.
• W1489389999 countsByYear W14893899992014 @default.
• W1489389999 countsByYear W14893899992019 @default.
• W1489389999 crossrefType "journal-article" @default.
• W1489389999 hasAuthorship W1489389999A5035904647 @default.
• W1489389999 hasAuthorship W1489389999A5063483109 @default.
• W1489389999 hasAuthorship W1489389999A5076741471 @default.
• W1489389999 hasAuthorship W1489389999A5091383746 @default.
• W1489389999 hasBestOaLocation W14893899991 @default.
• W1489389999 hasConcept C126322002 @default.
• W1489389999 hasConcept C128057223 @default.
• W1489389999 hasConcept C153911025 @default.
• W1489389999 hasConcept C179464577 @default.
• W1489389999 hasConcept C185592680 @default.
• W1489389999 hasConcept C189938988 @default.
• W1489389999 hasConcept C190283241 @default.
• W1489389999 hasConcept C203014093 @default.
• W1489389999 hasConcept C2776090121 @default.
• W1489389999 hasConcept C2776151105 @default.
• W1489389999 hasConcept C2911091166 @default.
• W1489389999 hasConcept C31573885 @default.
• W1489389999 hasConcept C55493867 @default.
• W1489389999 hasConcept C66008609 @default.
• W1489389999 hasConcept C71924100 @default.
• W1489389999 hasConcept C86803240 @default.
• W1489389999 hasConcept C8891405 @default.
• W1489389999 hasConcept C95444343 @default.
• W1489389999 hasConceptScore W1489389999C126322002 @default.
• W1489389999 hasConceptScore W1489389999C128057223 @default.
• W1489389999 hasConceptScore W1489389999C153911025 @default.
• W1489389999 hasConceptScore W1489389999C179464577 @default.
• W1489389999 hasConceptScore W1489389999C185592680 @default.
• W1489389999 hasConceptScore W1489389999C189938988 @default.
• W1489389999 hasConceptScore W1489389999C190283241 @default.
• W1489389999 hasConceptScore W1489389999C203014093 @default.
• W1489389999 hasConceptScore W1489389999C2776090121 @default.
• W1489389999 hasConceptScore W1489389999C2776151105 @default.
• W1489389999 hasConceptScore W1489389999C2911091166 @default.
• W1489389999 hasConceptScore W1489389999C31573885 @default.
• W1489389999 hasConceptScore W1489389999C55493867 @default.

• next