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- W1489413125 endingPage "170" @default.
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- W1489413125 abstract "Over the past few years, the molecular genetic changes underlying cartilaginous and bone tumor development and progression have been increasingly elucidated. However, the development of optimal treatment strategies for some of these entities has been greatly complicated by the large number of subtypes, the heterogeneity in their genetics and biological behavior, and the rarity of these tumors. In addition, inconsistencies have emerged from different studies examining prognostic factors, probably as a result of different study designs and treatment protocols, confounding variables associated with retrospective analyses and the use of diverse molecular methods. In order to resolve these issues, prognostic factors should be validated using uniform and multiple methods in both retrospective investigations and prospective multi-center studies. The advent of the human genome map and molecular techniques, such as microarray-based copy number and gene expression profiling, provide a new approach to classifying tumors and promise to improve our ability to predict both the probability of metastasis and overall clinical course. In addition, an understanding of the molecular biology of these tumors is leading to the identification of targets for novel therapeutic approaches." @default.
- W1489413125 created "2016-06-24" @default.
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- W1489413125 creator A5004696064 @default.
- W1489413125 creator A5075737353 @default.
- W1489413125 creator A5085381551 @default.
- W1489413125 date "2010-01-01" @default.
- W1489413125 modified "2023-09-25" @default.
- W1489413125 title "Genetic Aspects of Bone Tumors" @default.
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