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- W1489413390 abstract "Replicative senescence is of fundamental importance for the process of cellular aging, since it is a property of most of our somatic cells. Here, we elucidated this process by comparing gene expression changes, measured by RNA-seq, in fibroblasts originating from two different tissues, embryonic lung (MRC-5) and foreskin (HFF), at five different time points during their transition into senescence. Although the expression patterns of both fibroblast cell lines can be clearly distinguished, the similar differential expression of an ensemble of genes was found to correlate well with their transition into senescence, with only a minority of genes being cell line specific. Clustering-based approaches further revealed common signatures between the cell lines. Investigation of the mRNA expression levels at various time points during the lifespan of either of the fibroblasts resulted in a number of monotonically up- and downregulated genes which clearly showed a novel strong link to aging and senescence related processes which might be functional. In terms of expression profiles of differentially expressed genes with age, common genes identified here have the potential to rule the transition into senescence of embryonic lung and foreskin fibroblasts irrespective of their different cellular origin." @default.
- W1489413390 created "2016-06-24" @default.
- W1489413390 creator A5000809255 @default.
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- W1489413390 creator A5087583207 @default.
- W1489413390 date "2015-01-01" @default.
- W1489413390 modified "2023-10-16" @default.
- W1489413390 title "Similarities in Gene Expression Profiles during<i>In Vitro</i>Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts" @default.
- W1489413390 cites W1515485668 @default.
- W1489413390 cites W1551753600 @default.
- W1489413390 cites W1552049854 @default.
- W1489413390 cites W1559752086 @default.
- W1489413390 cites W1600001384 @default.
- W1489413390 cites W177968531 @default.
- W1489413390 cites W1862106564 @default.
- W1489413390 cites W1964440144 @default.
- W1489413390 cites W1967073403 @default.
- W1489413390 cites W1969353942 @default.
- W1489413390 cites W1970028828 @default.
- W1489413390 cites W1972724222 @default.
- W1489413390 cites W1973268693 @default.
- W1489413390 cites W1974481403 @default.
- W1489413390 cites W1980886467 @default.
- W1489413390 cites W1982617894 @default.
- W1489413390 cites W1982985869 @default.
- W1489413390 cites W1983077307 @default.
- W1489413390 cites W1985028322 @default.
- W1489413390 cites W1985213868 @default.
- W1489413390 cites W1989009382 @default.
- W1489413390 cites W1996713338 @default.
- W1489413390 cites W1997012271 @default.
- W1489413390 cites W2001160697 @default.
- W1489413390 cites W2001847085 @default.
- W1489413390 cites W2004314923 @default.
- W1489413390 cites W2009127368 @default.
- W1489413390 cites W2011455390 @default.
- W1489413390 cites W2012016911 @default.
- W1489413390 cites W2014002877 @default.
- W1489413390 cites W2015709471 @default.
- W1489413390 cites W2019902843 @default.
- W1489413390 cites W2020717634 @default.
- W1489413390 cites W2021081647 @default.
- W1489413390 cites W2023889729 @default.
- W1489413390 cites W2024105546 @default.
- W1489413390 cites W2027138069 @default.
- W1489413390 cites W2027700437 @default.
- W1489413390 cites W2028947788 @default.
- W1489413390 cites W2029868343 @default.
- W1489413390 cites W2036455733 @default.
- W1489413390 cites W2038140014 @default.
- W1489413390 cites W2045264627 @default.
- W1489413390 cites W2045883614 @default.
- W1489413390 cites W2046730243 @default.
- W1489413390 cites W2047177657 @default.
- W1489413390 cites W2049446122 @default.
- W1489413390 cites W2051379856 @default.
- W1489413390 cites W2051714112 @default.
- W1489413390 cites W2052411122 @default.
- W1489413390 cites W2053200860 @default.
- W1489413390 cites W2058320003 @default.
- W1489413390 cites W2058880531 @default.
- W1489413390 cites W2060010556 @default.
- W1489413390 cites W2068767798 @default.
- W1489413390 cites W2071673220 @default.
- W1489413390 cites W2077450385 @default.
- W1489413390 cites W2080717926 @default.
- W1489413390 cites W2083296923 @default.
- W1489413390 cites W2086877549 @default.
- W1489413390 cites W2091984039 @default.
- W1489413390 cites W2100604737 @default.
- W1489413390 cites W2101404749 @default.
- W1489413390 cites W2103235451 @default.
- W1489413390 cites W2104908670 @default.
- W1489413390 cites W2105924489 @default.
- W1489413390 cites W2113468873 @default.
- W1489413390 cites W2114104545 @default.
- W1489413390 cites W2114565252 @default.
- W1489413390 cites W2115852450 @default.
- W1489413390 cites W2116437342 @default.
- W1489413390 cites W2119028566 @default.
- W1489413390 cites W2126947862 @default.
- W1489413390 cites W2130304979 @default.
- W1489413390 cites W2131431946 @default.
- W1489413390 cites W2135546199 @default.
- W1489413390 cites W2138207763 @default.
- W1489413390 cites W2140729960 @default.
- W1489413390 cites W2145391392 @default.
- W1489413390 cites W2151204963 @default.
- W1489413390 cites W2152239989 @default.
- W1489413390 cites W2155820414 @default.
- W1489413390 cites W2158976459 @default.
- W1489413390 cites W2161080185 @default.
- W1489413390 cites W2164644562 @default.