FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489452114> ?p ?o ?g. }

• W1489452114 endingPage "e10" @default.
• W1489452114 startingPage "84" @default.
• W1489452114 abstract "Background Autoimmune gastrointestinal dysmotility (AGID) is a limited form of dysautonomia. The only proven effector to date is IgG specific for ganglionic nicotinic-acetylcholine receptors containing α3 subunits [α3*- nicotinic acetylcholine receptor (nAChR)]. Rabbits immunized with recombinant α3-polypeptide produce α3*-nAChR autoantibodies, and profound AGID ensues. Human and rabbit α3*-nAChR-specific-IgGs induce transient hypomotility when injected into mice. Here, we describe success and problems encountered inducing gastrointestinal hypomotility in mice by active immunization. Methods We repeatedly injected young adult mice of seven different strains susceptible to autoimmunity (spontaneous diabetes or neural antigen immunization-induced myasthenia gravis or encephalomyelitis) with: (i) α3-polypeptide, intradermally or (ii) live α3*-nAChR-expressing xenogeneic cells, intraperitoneally. We measured serum α3*-nAChR-IgG twice monthly, and terminally assessed blue dye gastrointestinal transit, total small intestinal α3*-nAChR content (radiochemically) and myenteric plexus neuron numbers (immunohistochemically, ileal–jejunal whole-mount preparations). Key Results Standard cutaneous inoculation with α3-polypeptide was minimally immunogenic, regardless of dose. Intraperitoneally injected live cells were potently immunogenic. Self-reactive α3*-nAChR-IgG was induced only by rodent immunogen; small intestinal transit slowing and enteric α3*-nAChR loss required high serum levels. Ganglionic neurons were not lost. Conclusions & Inferences Autoimmune gastrointestinal dysmotility is inducible in mice by active immunization. Accompanying enteric α3*-nAChR reduction without neuronal death is consistent with an IgG-mediated rather than T cell-mediated pathogenesis, as is improvement of symptoms in patients receiving antibody-depleting therapies." @default.
• W1489452114 created "2016-06-24" @default.
• W1489452114 creator A5004632935 @default.
• W1489452114 creator A5006057012 @default.
• W1489452114 creator A5022758815 @default.
• W1489452114 creator A5026032767 @default.
• W1489452114 creator A5029140980 @default.
• W1489452114 creator A5055122406 @default.
• W1489452114 creator A5075435687 @default.
• W1489452114 date "2012-10-17" @default.
• W1489452114 modified "2023-09-27" @default.
• W1489452114 title "Gastrointestinal hypomotility with loss of enteric nicotinic acetylcholine receptors: active immunization model in mice" @default.
• W1489452114 cites W1609538723 @default.
• W1489452114 cites W1896921323 @default.
• W1489452114 cites W1991027093 @default.
• W1489452114 cites W1999290750 @default.
• W1489452114 cites W2022585600 @default.
• W1489452114 cites W2051511161 @default.
• W1489452114 cites W2054437461 @default.
• W1489452114 cites W2060166306 @default.
• W1489452114 cites W2069835331 @default.
• W1489452114 cites W2092102896 @default.
• W1489452114 cites W2096265245 @default.
• W1489452114 cites W2108349925 @default.
• W1489452114 cites W2125229293 @default.
• W1489452114 cites W2131381171 @default.
• W1489452114 cites W2136548564 @default.
• W1489452114 cites W2138886795 @default.
• W1489452114 cites W2143761442 @default.
• W1489452114 cites W2151600206 @default.
• W1489452114 cites W2166446573 @default.
• W1489452114 cites W2341201500 @default.
• W1489452114 doi "https://doi.org/10.1111/nmo.12030" @default.
• W1489452114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3535544" @default.
• W1489452114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23072523" @default.
• W1489452114 hasPublicationYear "2012" @default.
• W1489452114 type Work @default.
• W1489452114 sameAs 1489452114 @default.
• W1489452114 citedByCount "10" @default.
• W1489452114 countsByYear W14894521142014 @default.
• W1489452114 countsByYear W14894521142015 @default.
• W1489452114 countsByYear W14894521142016 @default.
• W1489452114 countsByYear W14894521142017 @default.
• W1489452114 countsByYear W14894521142018 @default.
• W1489452114 countsByYear W14894521142019 @default.
• W1489452114 countsByYear W14894521142020 @default.
• W1489452114 countsByYear W14894521142021 @default.
• W1489452114 countsByYear W14894521142022 @default.
• W1489452114 crossrefType "journal-article" @default.
• W1489452114 hasAuthorship W1489452114A5004632935 @default.
• W1489452114 hasAuthorship W1489452114A5006057012 @default.
• W1489452114 hasAuthorship W1489452114A5022758815 @default.
• W1489452114 hasAuthorship W1489452114A5026032767 @default.
• W1489452114 hasAuthorship W1489452114A5029140980 @default.
• W1489452114 hasAuthorship W1489452114A5055122406 @default.
• W1489452114 hasAuthorship W1489452114A5075435687 @default.
• W1489452114 hasBestOaLocation W14894521142 @default.
• W1489452114 hasConcept C126322002 @default.
• W1489452114 hasConcept C134018914 @default.
• W1489452114 hasConcept C159654299 @default.
• W1489452114 hasConcept C170493617 @default.
• W1489452114 hasConcept C188987157 @default.
• W1489452114 hasConcept C203014093 @default.
• W1489452114 hasConcept C204232928 @default.
• W1489452114 hasConcept C2776907353 @default.
• W1489452114 hasConcept C2777439022 @default.
• W1489452114 hasConcept C2778943623 @default.
• W1489452114 hasConcept C2779570518 @default.
• W1489452114 hasConcept C2780801004 @default.
• W1489452114 hasConcept C71924100 @default.
• W1489452114 hasConcept C80161118 @default.
• W1489452114 hasConcept C86803240 @default.
• W1489452114 hasConceptScore W1489452114C126322002 @default.
• W1489452114 hasConceptScore W1489452114C134018914 @default.
• W1489452114 hasConceptScore W1489452114C159654299 @default.
• W1489452114 hasConceptScore W1489452114C170493617 @default.
• W1489452114 hasConceptScore W1489452114C188987157 @default.
• W1489452114 hasConceptScore W1489452114C203014093 @default.
• W1489452114 hasConceptScore W1489452114C204232928 @default.
• W1489452114 hasConceptScore W1489452114C2776907353 @default.
• W1489452114 hasConceptScore W1489452114C2777439022 @default.
• W1489452114 hasConceptScore W1489452114C2778943623 @default.
• W1489452114 hasConceptScore W1489452114C2779570518 @default.
• W1489452114 hasConceptScore W1489452114C2780801004 @default.
• W1489452114 hasConceptScore W1489452114C71924100 @default.
• W1489452114 hasConceptScore W1489452114C80161118 @default.
• W1489452114 hasConceptScore W1489452114C86803240 @default.
• W1489452114 hasIssue "1" @default.
• W1489452114 hasLocation W14894521141 @default.
• W1489452114 hasLocation W14894521142 @default.
• W1489452114 hasLocation W14894521143 @default.
• W1489452114 hasLocation W14894521144 @default.
• W1489452114 hasOpenAccess W1489452114 @default.
• W1489452114 hasPrimaryLocation W14894521141 @default.
• W1489452114 hasRelatedWork W1214975925 @default.
• W1489452114 hasRelatedWork W1489452114 @default.
• W1489452114 hasRelatedWork W2034583712 @default.
• W1489452114 hasRelatedWork W2039298574 @default.

• next