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• W1489471503 abstract "The objective was to review the major differences of Huntington disease (HD) in Asian population from those in the Caucasian population.Data cited in this review were obtained from PubMed database and China National Knowledge Infrastructure (CNKI) from 1994 to 2014. All the papers were written in English or Chinese languages, with the terms of Asia/Asian, HD, genotype, epidemiology, phenotype, and treatment used for the literature search.From the PubMed database, we included the articles and reviews which contained the HD patients' data from Asian countries. From the CNKI, we excluded the papers which were not original research. Due to the language's restrictions, those data published in other languages were not included.In total, 50 papers were cited in this review, authors of which were from the mainland of China, Japan, India, Thailand, Taiwan (China), Korea, and western countries.The lower epidemiology in Asians can be partly explained by the less cytosine-adenine-guanine repeats, different haplotypes, and CCG polymorphisms. For the physicians, atypical clinical profiles such as the initial symptom of ataxia, movement abnormalities of Parkinsonism, dystonia, or tics need to be paid more attention to and suggest gene testing if necessary. Moreover, some pathogenesis studies may help progress some new advanced treatments. The clinicians in Asian especially in China should promote the usage of genetic testing and put more effects in rehabilitation, palliative care, and offer comfort of patients and their families. The unified HD rating scale also needs to be popularized in Asia to assist in evaluating the progression of HD." @default.
• W1489471503 created "2016-06-24" @default.
• W1489471503 creator A5034991387 @default.
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• W1489471503 date "2015-07-05" @default.
• W1489471503 modified "2023-10-16" @default.
• W1489471503 title "Huntington Disease in Asia" @default.
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• W1489471503 doi "https://doi.org/10.4103/0366-6999.159359" @default.
• W1489471503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4733723" @default.
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