Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489486554> ?p ?o ?g. }
- W1489486554 endingPage "8971" @default.
- W1489486554 startingPage "8965" @default.
- W1489486554 abstract "The T cell antigen receptor on most mature T cells consists of at least seven chains (the variable, clone-specific alpha and beta chains, and five constant chains, CD3-gamma, -delta, -epsilon, and -zeta 2). These chains assemble rapidly after synthesis in the endoplasmic reticulum. In this paper we describe an additional protein termed TRAP (T cell receptor associated protein) that is transiently associated with at least some of the newly synthesized murine receptor chains. TRAP remains bound to receptor subunits as they assemble for about 10-20 min after synthesis. Rapid dissociation of TRAP ensues. This can be blocked by manipulations that inhibit endoplasmic reticulum to Golgi transport or with agents that inhibit organelle acidification. In mutant T cells that fail to synthesize the beta chains, the partial complex fails to reach the Golgi system. Despite this, TRAP dissociates with kinetics similar to those observed in the parental T cells. Thus, our studies indicate that the dissociation of TRAP occurs in a pre-Golgi compartment by a process that requires an acidic intraorganellar pH." @default.
- W1489486554 created "2016-06-24" @default.
- W1489486554 creator A5000877747 @default.
- W1489486554 creator A5032113574 @default.
- W1489486554 creator A5062182530 @default.
- W1489486554 creator A5073726266 @default.
- W1489486554 creator A5080675458 @default.
- W1489486554 creator A5089066152 @default.
- W1489486554 date "1988-06-01" @default.
- W1489486554 modified "2023-10-18" @default.
- W1489486554 title "Association and dissociation of the murine T cell receptor associated protein (TRAP). Early events in the biosynthesis of a multisubunit receptor." @default.
- W1489486554 cites W113442559 @default.
- W1489486554 cites W1534685762 @default.
- W1489486554 cites W1561414866 @default.
- W1489486554 cites W1573759787 @default.
- W1489486554 cites W1587051516 @default.
- W1489486554 cites W1596138381 @default.
- W1489486554 cites W1603259753 @default.
- W1489486554 cites W1642708427 @default.
- W1489486554 cites W1968569160 @default.
- W1489486554 cites W1971376791 @default.
- W1489486554 cites W1989526931 @default.
- W1489486554 cites W1990747840 @default.
- W1489486554 cites W1997572654 @default.
- W1489486554 cites W1997662437 @default.
- W1489486554 cites W1999298531 @default.
- W1489486554 cites W2002164494 @default.
- W1489486554 cites W2006736908 @default.
- W1489486554 cites W2014394244 @default.
- W1489486554 cites W2024739169 @default.
- W1489486554 cites W2025935390 @default.
- W1489486554 cites W2035826838 @default.
- W1489486554 cites W2036160208 @default.
- W1489486554 cites W2042762503 @default.
- W1489486554 cites W2045217835 @default.
- W1489486554 cites W2046737303 @default.
- W1489486554 cites W2056917962 @default.
- W1489486554 cites W2061806013 @default.
- W1489486554 cites W2064072571 @default.
- W1489486554 cites W2070379407 @default.
- W1489486554 cites W2080052508 @default.
- W1489486554 cites W2080476991 @default.
- W1489486554 cites W2081760133 @default.
- W1489486554 cites W2083999896 @default.
- W1489486554 cites W2088819006 @default.
- W1489486554 cites W2090228650 @default.
- W1489486554 cites W2109189984 @default.
- W1489486554 cites W2118690285 @default.
- W1489486554 cites W2145835877 @default.
- W1489486554 cites W2147347701 @default.
- W1489486554 cites W2149736282 @default.
- W1489486554 cites W2151246171 @default.
- W1489486554 cites W2164179462 @default.
- W1489486554 cites W2164358316 @default.
- W1489486554 cites W88485149 @default.
- W1489486554 doi "https://doi.org/10.1016/s0021-9258(18)68402-9" @default.
- W1489486554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3259950" @default.
- W1489486554 hasPublicationYear "1988" @default.
- W1489486554 type Work @default.
- W1489486554 sameAs 1489486554 @default.
- W1489486554 citedByCount "48" @default.
- W1489486554 countsByYear W14894865542021 @default.
- W1489486554 crossrefType "journal-article" @default.
- W1489486554 hasAuthorship W1489486554A5000877747 @default.
- W1489486554 hasAuthorship W1489486554A5032113574 @default.
- W1489486554 hasAuthorship W1489486554A5062182530 @default.
- W1489486554 hasAuthorship W1489486554A5073726266 @default.
- W1489486554 hasAuthorship W1489486554A5080675458 @default.
- W1489486554 hasAuthorship W1489486554A5089066152 @default.
- W1489486554 hasBestOaLocation W14894865541 @default.
- W1489486554 hasConcept C102931765 @default.
- W1489486554 hasConcept C104317684 @default.
- W1489486554 hasConcept C12554922 @default.
- W1489486554 hasConcept C147789679 @default.
- W1489486554 hasConcept C170493617 @default.
- W1489486554 hasConcept C185592680 @default.
- W1489486554 hasConcept C553450214 @default.
- W1489486554 hasConcept C55493867 @default.
- W1489486554 hasConcept C86803240 @default.
- W1489486554 hasConcept C95444343 @default.
- W1489486554 hasConceptScore W1489486554C102931765 @default.
- W1489486554 hasConceptScore W1489486554C104317684 @default.
- W1489486554 hasConceptScore W1489486554C12554922 @default.
- W1489486554 hasConceptScore W1489486554C147789679 @default.
- W1489486554 hasConceptScore W1489486554C170493617 @default.
- W1489486554 hasConceptScore W1489486554C185592680 @default.
- W1489486554 hasConceptScore W1489486554C553450214 @default.
- W1489486554 hasConceptScore W1489486554C55493867 @default.
- W1489486554 hasConceptScore W1489486554C86803240 @default.
- W1489486554 hasConceptScore W1489486554C95444343 @default.
- W1489486554 hasIssue "18" @default.
- W1489486554 hasLocation W14894865541 @default.
- W1489486554 hasOpenAccess W1489486554 @default.
- W1489486554 hasPrimaryLocation W14894865541 @default.
- W1489486554 hasRelatedWork W1969998872 @default.
- W1489486554 hasRelatedWork W1978251059 @default.
- W1489486554 hasRelatedWork W1998749221 @default.
- W1489486554 hasRelatedWork W1999199037 @default.