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• W1489503277 abstract "Progression of activated EGF receptor ( EGFR ) through the endocytic pathway regulates EGFR signaling. Here we show that a non‐ubiquitinated EGFR mutant, unable to bind the endosomal‐sorting complex required for transport ( ESCRT ) component, Hrs , is not efficiently targeted onto intraluminal vesicles ( ILVs ) of multivesicular endosomes/bodies ( MVBs ). Moreover, ubiquitination and ESCRT engagement of activated EGFR are required for EGF ‐stimulated ILV formation. Non‐ubiquitinated EGFRs enter clathrin‐coated tubules emanating from MVBs and show enhanced recycling to the plasma membrane, compared to wild‐type EGFR ." @default.
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• W1489503277 date "2011-11-22" @default.
• W1489503277 modified "2023-10-02" @default.
• W1489503277 title "The Role of EGF Receptor Ubiquitination in Regulating Its Intracellular Traffic" @default.
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• W1489503277 doi "https://doi.org/10.1111/j.1600-0854.2011.01305.x" @default.
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