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- W1489572085 abstract "Unidentified breast milk factors may explain some of the observed differences in neurodevelopment and infectious diseases between formula-fed and breast-fed infants. Breast milk contains MFGM, a source of several bioactive components, whilst infant formula (IF) does not. A double-blind RCT was performed to elucidate whether supplementation of formula with bovine MFGM would improve neurodevelopment and reduce morbidity in infectious diseases. Stratified for sex, 160 healthy term infants <2 mo were randomized to standard formula (SF) or experimental formula (EF) supplemented with a bovine MFGM-enriched fraction until 6 mo of age. Breast-fed infants (n=80) served as a reference group (BFR). Cognitive, motor and verbal function was assessed using Bayley III at 12 mo of age. Disease symptoms were recorded prospectively by parents. The cognitive score (mean ±SD) was higher in the EF group (105.8 ± 9.2) than in the SF group (101.8 ± 8.0), p=0.008, and there was no difference in cognitive score between the EF group and the BFR group (106.4 ± 9.5), p=0.73. There were no differences in motor or verbal scores between the EF and SF groups. The EF group had significantly lower incidence of acute otitis media (p = 0.034) and use of antipyretics (p= 0.021) during the first 6 mo compared to the SF group. In conclusion, bovine MFGM includes factors essential for optimal development of both cognitive and immune function and can be supplemented to IF." @default.
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- W1489572085 date "2014-04-01" @default.
- W1489572085 modified "2023-10-16" @default.
- W1489572085 title "Supplementation of infant formula with milk fat globule membranes improves cognitive performance and reduces infections in formula‐fed infants (38.2)" @default.
- W1489572085 doi "https://doi.org/10.1096/fasebj.28.1_supplement.38.2" @default.
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