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• W1489591882 startingPage "164" @default.
• W1489591882 abstract "LINE‐1 (long interspersed nuclear elements) retrotransposons constitute a large family of retrotransposable elements, accounting for 17% of the human genome. They encode proteins required for their own mobilization, including a reverse transcriptase (RT) enzyme highly expressed in mouse embryos and mouse and human cancer cells and repressed in somatic differentiated healthy cells. We have found that reverse transcription takes place in early murine embryos, yielding an increase in LINE‐1 copy number during preimplantation development, which also occurs in tumor progression. RT inhibition irreversibly arrests embryo development, reduces cancer cell proliferation, promotes differentiation, antagonizes tumor growth, and causes a global reprogramming of transcription profiles. These results strongly suggest that a previously unrecognized RT‐dependent regulatory mechanism operates during preimplantation development, is repressed during differentiation to normal tissues, and, when erroneously reactivated in adult life, promotes cell transformation and cancer progression by “resurrecting” embryonic transcriptional pathways. The RT‐dependent mechanism emerges as a major source of genetic and epigenetic changes with physiological, pathological, and evolutionary implications." @default.
• W1489591882 created "2016-06-24" @default.
• W1489591882 creator A5027416476 @default.
• W1489591882 date "2015-01-13" @default.
• W1489591882 modified "2023-10-03" @default.
• W1489591882 title "A LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis" @default.
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• W1489591882 doi "https://doi.org/10.1111/nyas.12637" @default.
• W1489591882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25586649" @default.
• W1489591882 hasPublicationYear "2015" @default.
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