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- W1489597942 abstract "Abstract Cell kinetics of arterial endothelial cells were studied in the 105- to 165-day period after the initiation of atherosclerosis in swine abdominal aorta by balloon denudation followed by a hyperlipidemic diet. One group of swine was continuously on a hyperlipidemic diet from Day 0 to Day 165; another group on Day 60 was placed on a normolipidemic mash diet. Between Days 105 and 165, the amount of endothelial cell loss over lesion areas in the hyperlipidemic group was approximately 40%, while virtually no loss occurred over lesion areas in the group placed on the mash diet at Day 60. This diet, when fed for 14 months, is known to produce regression of atherosclerosis in swine. Continuous endothelial cell loss of abnormal amount, as occurred over lesion areas of the hyperlipidemic group in this study, may result in a breach (albeit a transient one) in the endothelial cell barrier, and allow the entry of injurious substances such as platelets or lipoproteins which enhance the development of atherosclerosis. The reversal of this endothelial cell loss by a mash diet is possibly one of the first events in the regression of the atherosclerotic lesion." @default.
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- W1489597942 date "1981-10-01" @default.
- W1489597942 modified "2023-10-16" @default.
- W1489597942 title "Population dynamics of arterial cells during atherogenesis" @default.
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- W1489597942 doi "https://doi.org/10.1016/0014-4800(81)90056-3" @default.
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