FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489600500> ?p ?o ?g. }

• W1489600500 endingPage "1226" @default.
• W1489600500 startingPage "1214" @default.
• W1489600500 abstract "Biogenesis of high-density lipoproteins (HDL) is coupled to the transmembrane protein, ATP-binding cassette transporter A1 (ABCA1), which transports phospholipid (PL) from the inner to the outer membrane monolayer. Using a combination of computational and experimental approaches, we show that increased outer lipid monolayer surface density, driven by excess PL or membrane insertion of amphipathic helices, results in pleating of the outer monolayer to form membrane-attached discoidal bilayers. Apolipoprotein (apo)A-I accelerates and stabilizes the pleats. In the absence of apoA-I, pleats collapse to form vesicles. These results mimic cells overexpressing ABCA1 that, in the absence of apoA-I, form and release vesicles. We conclude that the basic driving force for nascent discoidal HDL assembly is a PL pump-induced surface density increase that produces lipid monolayer pleating. We then argue that ABCA1 forms an extracellular reservoir containing an isolated pressurized lipid monolayer decoupled from the transbilayer density buffering of cholesterol." @default.
• W1489600500 created "2016-06-24" @default.
• W1489600500 creator A5008610311 @default.
• W1489600500 creator A5015099364 @default.
• W1489600500 creator A5028220327 @default.
• W1489600500 creator A5034860266 @default.
• W1489600500 creator A5051286588 @default.
• W1489600500 creator A5055416469 @default.
• W1489600500 creator A5056329233 @default.
• W1489600500 creator A5062257605 @default.
• W1489600500 creator A5070217159 @default.
• W1489600500 creator A5072257509 @default.
• W1489600500 creator A5090086215 @default.
• W1489600500 creator A5090371335 @default.
• W1489600500 date "2015-07-01" @default.
• W1489600500 modified "2023-10-15" @default.
• W1489600500 title "Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly" @default.
• W1489600500 cites W1510117994 @default.
• W1489600500 cites W1591670239 @default.
• W1489600500 cites W1607399348 @default.
• W1489600500 cites W165264657 @default.
• W1489600500 cites W1813550242 @default.
• W1489600500 cites W1860908381 @default.
• W1489600500 cites W1966078827 @default.
• W1489600500 cites W1971057241 @default.
• W1489600500 cites W1972114344 @default.
• W1489600500 cites W1976971919 @default.
• W1489600500 cites W1983592129 @default.
• W1489600500 cites W1990507892 @default.
• W1489600500 cites W1993012149 @default.
• W1489600500 cites W1995770348 @default.
• W1489600500 cites W2004644461 @default.
• W1489600500 cites W2006909813 @default.
• W1489600500 cites W2008937801 @default.
• W1489600500 cites W2009832539 @default.
• W1489600500 cites W2009979715 @default.
• W1489600500 cites W2011078603 @default.
• W1489600500 cites W2012650964 @default.
• W1489600500 cites W2014170297 @default.
• W1489600500 cites W2024616958 @default.
• W1489600500 cites W2025155898 @default.
• W1489600500 cites W2026677644 @default.
• W1489600500 cites W2029667189 @default.
• W1489600500 cites W2032513433 @default.
• W1489600500 cites W2035266068 @default.
• W1489600500 cites W2041136477 @default.
• W1489600500 cites W2043154979 @default.
• W1489600500 cites W2043750940 @default.
• W1489600500 cites W2048387303 @default.
• W1489600500 cites W2051864856 @default.
• W1489600500 cites W2053911002 @default.
• W1489600500 cites W2060956030 @default.
• W1489600500 cites W2063414626 @default.
• W1489600500 cites W2065263199 @default.
• W1489600500 cites W2069655536 @default.
• W1489600500 cites W2070060517 @default.
• W1489600500 cites W2084093170 @default.
• W1489600500 cites W2084141366 @default.
• W1489600500 cites W2084805181 @default.
• W1489600500 cites W2119267663 @default.
• W1489600500 cites W2123715983 @default.
• W1489600500 cites W2135317116 @default.
• W1489600500 cites W2138657570 @default.
• W1489600500 cites W2143902201 @default.
• W1489600500 cites W2145813488 @default.
• W1489600500 cites W2185709413 @default.
• W1489600500 doi "https://doi.org/10.1016/j.str.2015.05.010" @default.
• W1489600500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4496276" @default.
• W1489600500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26095027" @default.
• W1489600500 hasPublicationYear "2015" @default.
• W1489600500 type Work @default.
• W1489600500 sameAs 1489600500 @default.
• W1489600500 citedByCount "36" @default.
• W1489600500 countsByYear W14896005002015 @default.
• W1489600500 countsByYear W14896005002016 @default.
• W1489600500 countsByYear W14896005002017 @default.
• W1489600500 countsByYear W14896005002018 @default.
• W1489600500 countsByYear W14896005002019 @default.
• W1489600500 countsByYear W14896005002020 @default.
• W1489600500 countsByYear W14896005002021 @default.
• W1489600500 countsByYear W14896005002022 @default.
• W1489600500 countsByYear W14896005002023 @default.
• W1489600500 crossrefType "journal-article" @default.
• W1489600500 hasAuthorship W1489600500A5008610311 @default.
• W1489600500 hasAuthorship W1489600500A5015099364 @default.
• W1489600500 hasAuthorship W1489600500A5028220327 @default.
• W1489600500 hasAuthorship W1489600500A5034860266 @default.
• W1489600500 hasAuthorship W1489600500A5051286588 @default.
• W1489600500 hasAuthorship W1489600500A5055416469 @default.
• W1489600500 hasAuthorship W1489600500A5056329233 @default.
• W1489600500 hasAuthorship W1489600500A5062257605 @default.
• W1489600500 hasAuthorship W1489600500A5070217159 @default.
• W1489600500 hasAuthorship W1489600500A5072257509 @default.
• W1489600500 hasAuthorship W1489600500A5090086215 @default.
• W1489600500 hasAuthorship W1489600500A5090371335 @default.
• W1489600500 hasBestOaLocation W14896005001 @default.
• W1489600500 hasConcept C104317684 @default.
• W1489600500 hasConcept C12554922 @default.

• next