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- W1489628140 abstract "Proc Amer Assoc Cancer Res, Volume 46, 20055669 Tumor cell migration in capillaries is an important step in the metastatic process. However, the mechanism of cancer cell migration in very narrow vessels is incompletely understood. In order to visualize cytoplasmic and nuclear dynamics of cells migrating in capillaries, red fluorescent protein (RFP) was expressed in the cytoplasm, and green fluorescent protein (GFP), linked to histone H2B, was expressed in the nucleus of human HT1080 fibrosarcoma cells. Immediately after the cells were injected in the heart of nude mice, a skin-flap on the abdomen was made and spread on a flat stand. We could observe highly elongated cancer cells in capillaries in the skin-flap in living mice. The cells in the capillaries had both their cytoplasm and nuclei elongated to fit in the narrow diameter of the capillaries. The migration velocities of the cancer cells in the capillaries were measured by capturing images of the dual-color fluorescent cells over time. Eighty percent of the cells that were arrested in capillaries over 8 μm in diameter could migrate up to 48.3 μm/hr. In contrast, only 16 percent of the cells that were arrested in capillaries less than 8 μm in diameter could migrate at all. These data suggest that the minimum diameter of capillaries where cancer cells are able to migrate is approximately 8 μm. The use of the dual-color cancer cells labeled with different fluorescent proteins in the nucleus and cytoplasm and associated fluorescent imaging provides a powerful tool to understand the mechanism of cancer cell migration in small vessels." @default.
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- W1489628140 date "2005-05-01" @default.
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- W1489628140 title "Imaging capillary migration of tumor cells in live animals" @default.
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