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- W1489632596 abstract "Recibido: May 28th, 2009. Aceptado: September 10th, 2009. ABSTRACT. Stroke is one of the three leading causes of disability and death worldwide. Transient ischemic attacks (TIA) pose an increased risk of subsequent ischaemic stroke. Antiplatelet therapy, mainly aspirin, remains as first-line therapy to prevent recurrent TIA and/or ischemic strokes, and antihypertensives and cholesterol-lowering agents play also a key role in this stra- tegy. Policosanol, with cholesterol-lowering drug and concomitant antiplatelet effects, has shown protective effects on stroke models. Policosanol 20 mg/d added to aspirin during the acute phase of ischemic stroke and thereafter provided good results on neurological outcomes and recurrent events. This study assessed the benefits of policosanol 20 mg/d administered from hospital discharge up to 60 months thereafter in 55 patients of both sexes with ischaemic stroke who had previously suffered TIA. At each visit, clinical and neurological examination with the modified Canadian Neurological Scale, request on adverse experiences and laboratory tests were done. All new events were recorded. In addition to the previous TIA, the most frequent personal risk factors at baseline were hypertension (98.2 %), hypercholesterolemia (81.8 %), smoking (32.7 %) and coronary disease (29.1 %). All patients completed the study. Neurological score improved significantly and progressively during the first year, and such improvement persisted to study completion. Only five patients (9.1 %) suffer a new event: one new stroke, four new TIA. After three months, serum cholesterol significantly lowered (21. 3 %) compared with baseline, and this effect did not wear off, but improved after long-term therapy. The improvement of the neurological outcome correlated with TC reduction (r = 0.987). Treatment unchanged safety indicators. Then, treatment with policosanol 20 mg/d + aspirin 125 mg/d after hospital discharge produced good results in the neurological recovery, recurrence of events and cholesterol control in patients with ischemic stroke and a previous TIA, but these benefits should be confirmed in randomized, double-blind, controlled studies." @default.
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- W1489632596 date "2010-01-01" @default.
- W1489632596 modified "2023-09-26" @default.
- W1489632596 title "Effects of policosanol on patients with ischemic stroke with previous transient ischemic attack: a long-term follow-up" @default.
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