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• W1489636612 startingPage "1155" @default.
• W1489636612 abstract "N(6)-methyladenine (6mA) is one of the most abundant types of DNA methylation, and plays an important role in bacteria; however, its roles in higher eukaryotes, such as plants, insects, and mammals, have been considered less important. Recent studies highlight that 6mA does indeed occur, and that it plays an important role in eukaryotes, such as worm, fly, and green algae, and thus the regulation of 6mA has emerged as a novel epigenetic mechanism in higher eukaryotes. Despite this intriguing development, a number of important issues regarding its biological roles are yet to be addressed. In this review, we focus on the 5mC and 6mA modifications in terms of their production, distribution, and the erasure of 6mA in higher eukaryotes including mammals. We perform an analysis of the potential functions of 6mA, hence widening understanding of this new epigenetic mark in higher eukaryotes, and suggesting future studies in this field." @default.
• W1489636612 created "2016-06-24" @default.
• W1489636612 creator A5010918490 @default.
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• W1489636612 creator A5064271606 @default.
• W1489636612 creator A5074628946 @default.
• W1489636612 creator A5077060343 @default.
• W1489636612 date "2015-08-21" @default.
• W1489636612 modified "2023-10-15" @default.
• W1489636612 title "N⁶-methyladenine functions as a potential epigenetic mark in eukaryotes" @default.
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• W1489636612 doi "https://doi.org/10.1002/bies.201500076" @default.
• W1489636612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26293475" @default.

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