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- W1489648949 abstract "Topical microbicides have the potential to significantly impact the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) pandemic by providing vulnerable populations with a self administered method to prevent HIV infection. The identification of a safe and effective HIV‐specific, virucidal microbicide has not been a priority for development, as evidenced by their limited representation in the microbicide pipeline since safety concerns were raised for the nonspecific, detergent, virucide Nonoxynol‐9. The optimal virucidal microbicide would be one that targets not only cell‐free but also cell‐associated virus, acting as a pluripotent, HIV‐specific virucide, capable of targeting multiple steps in the HIV replication cycle. This potentially has been achieved through the discovery and development of the thioester‐based, S‐acyl‐2‐mercaptobenzamide compounds targeting the HIV‐1 NCp7 nucleocapsid zinc finger. Experimental evidence shows that these inhibitors interact with a highly conserved protein sequence in a covalent manner to prevent the replication of both cell‐free (virucidal) and cell‐associated virus by irreversibly ejecting the coordinated zinc ion from the protein, thus altering its structure." @default.
- W1489648949 created "2016-06-24" @default.
- W1489648949 creator A5013911638 @default.
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- W1489648949 creator A5022691579 @default.
- W1489648949 creator A5036354240 @default.
- W1489648949 creator A5081253935 @default.
- W1489648949 date "2008-01-01" @default.
- W1489648949 modified "2023-09-23" @default.
- W1489648949 title "Topical Microbicides: A Promising Approach for Controlling the AIDS Pandemic via Retroviral Zinc Finger Inhibitors" @default.
- W1489648949 cites W1505727107 @default.
- W1489648949 cites W1525927184 @default.
- W1489648949 cites W1529451750 @default.
- W1489648949 cites W1621280022 @default.
- W1489648949 cites W1628023582 @default.
- W1489648949 cites W1653610605 @default.
- W1489648949 cites W1680765385 @default.
- W1489648949 cites W1765618930 @default.
- W1489648949 cites W1930567567 @default.
- W1489648949 cites W1967023837 @default.
- W1489648949 cites W1971758177 @default.
- W1489648949 cites W1974054879 @default.
- W1489648949 cites W1975920443 @default.
- W1489648949 cites W1976683819 @default.
- W1489648949 cites W1976938776 @default.
- W1489648949 cites W1979148488 @default.
- W1489648949 cites W1980112481 @default.
- W1489648949 cites W1983812589 @default.
- W1489648949 cites W1986513426 @default.
- W1489648949 cites W1992645380 @default.
- W1489648949 cites W1993241533 @default.
- W1489648949 cites W1995453332 @default.
- W1489648949 cites W1996630539 @default.
- W1489648949 cites W1996888701 @default.
- W1489648949 cites W2003945592 @default.
- W1489648949 cites W2006370225 @default.
- W1489648949 cites W2011650141 @default.
- W1489648949 cites W2012325453 @default.
- W1489648949 cites W2013544460 @default.
- W1489648949 cites W2019730142 @default.
- W1489648949 cites W2023998603 @default.
- W1489648949 cites W2024600963 @default.
- W1489648949 cites W2025174090 @default.
- W1489648949 cites W2027373982 @default.
- W1489648949 cites W2028603136 @default.
- W1489648949 cites W2031520916 @default.
- W1489648949 cites W2039243741 @default.
- W1489648949 cites W2041049065 @default.
- W1489648949 cites W2041074982 @default.
- W1489648949 cites W2043409853 @default.
- W1489648949 cites W2048626266 @default.
- W1489648949 cites W2050989701 @default.
- W1489648949 cites W2052157498 @default.
- W1489648949 cites W2056603207 @default.
- W1489648949 cites W2062006468 @default.
- W1489648949 cites W2073159948 @default.
- W1489648949 cites W2076223391 @default.
- W1489648949 cites W2076799931 @default.
- W1489648949 cites W2078095448 @default.
- W1489648949 cites W2078157295 @default.
- W1489648949 cites W2079118745 @default.
- W1489648949 cites W2079404022 @default.
- W1489648949 cites W2079763953 @default.
- W1489648949 cites W2086589878 @default.
- W1489648949 cites W2089160203 @default.
- W1489648949 cites W2089610982 @default.
- W1489648949 cites W2093219399 @default.
- W1489648949 cites W2094782383 @default.
- W1489648949 cites W2099277378 @default.
- W1489648949 cites W2099689198 @default.
- W1489648949 cites W2101001184 @default.
- W1489648949 cites W2101770554 @default.
- W1489648949 cites W2104422107 @default.
- W1489648949 cites W2108622456 @default.
- W1489648949 cites W2110138914 @default.
- W1489648949 cites W2123459861 @default.
- W1489648949 cites W2123581489 @default.
- W1489648949 cites W2125105872 @default.
- W1489648949 cites W2129431697 @default.
- W1489648949 cites W2132370303 @default.
- W1489648949 cites W2135850403 @default.
- W1489648949 cites W2136309551 @default.
- W1489648949 cites W2140321641 @default.
- W1489648949 cites W2142042034 @default.
- W1489648949 cites W2145005290 @default.
- W1489648949 cites W2145515569 @default.
- W1489648949 cites W2145611790 @default.
- W1489648949 cites W2150793371 @default.
- W1489648949 cites W2154004911 @default.
- W1489648949 cites W2155737863 @default.
- W1489648949 cites W2159477638 @default.
- W1489648949 cites W2159741426 @default.
- W1489648949 cites W2162703129 @default.
- W1489648949 cites W2162744502 @default.
- W1489648949 cites W2171108507 @default.
- W1489648949 cites W2171689424 @default.
- W1489648949 cites W3022506119 @default.
- W1489648949 cites W4255037032 @default.