FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489659488> ?p ?o ?g. }

• W1489659488 endingPage "324" @default.
• W1489659488 startingPage "311" @default.
• W1489659488 abstract "Hao-Bo Guo, Jerry M. Parks, Alexander Johs, and Jeremy C. Smith20.1IntroductionMercury,aheavyelementthatiswidelydistributedthroughoutthebiosphere,isquitereactive, being susceptible to redox, photochemical, and various other chemicaltransformations.However,mercuryhasnoknownbeneficialbiologicalfunction,andis toxic to living organisms in all chemical forms.Mercury toxicity derives from its extremely high affinity for sulfur-containingligands such as cysteine and glutathione. Monomethylmercury, or simply methyl-mercury, is particularly toxic due to its extremely high thiolate affinity, its ability tocrosstheplacentalandblood–brainbarriers,anditspropensityforbioaccumulationin living organisms [1].Many bacteria that live in mercury-polluted environments possess a fascinatingsuiteofgenescalledthemercuryresistance,ormer,operon,whichencodesasetofproteins and enzymes that convert inorganic and organomercurial species tovolatile,lesstoxicelementalHg(0)[1,2].Themeroperonisencodedinplasmidsortransposons, and can be transferred to other organisms via horizontal genetransfer.Several proteins and enzymes are encoded by the mer operon. These include theperiplasmicHgtransporter,MerP, membrane-bound proteinssuchas MerC,MerT,and others, and the mercuric reductase, MerA. Broad-spectrum mercury-resistantorganisms also encode an organomercurial lyase, MerB, which is responsible fordegrading organomercury compounds such as methylmercury.Transcription of theGram-negative mer operon is regulated by MerR.In this chapter are described the results of recent investigations [3, 4] on thetranscriptional regulator, MerR, and the organomercurial lyase, MerB. First, acombined experimental and computational approach is detailed in which small-angle X-ray scattering (SAXS) experiments and molecular dynamics (MD) simula-tionswereusedtoprobethestructureanddynamicsofthetranscriptionalregulatorMerR. MD simulations have revealed the principal conformational changes inMerRuponHg(II)-binding,whichprovidesinsightintothemolecularmechanism" @default.
• W1489659488 created "2016-06-24" @default.
• W1489659488 creator A5007867266 @default.
• W1489659488 creator A5018366869 @default.
• W1489659488 creator A5037417242 @default.
• W1489659488 creator A5042897875 @default.
• W1489659488 date "2011-09-14" @default.
• W1489659488 modified "2023-09-27" @default.
• W1489659488 title "Mercury Detoxification by Bacteria: Simulations of Transcription Activation and MercuryCarbon Bond Cleavage" @default.
• W1489659488 cites W1586917242 @default.
• W1489659488 cites W1968366930 @default.
• W1489659488 cites W1975339453 @default.
• W1489659488 cites W1976499671 @default.
• W1489659488 cites W1977884904 @default.
• W1489659488 cites W1982418026 @default.
• W1489659488 cites W1982643455 @default.
• W1489659488 cites W1982773400 @default.
• W1489659488 cites W1989778057 @default.
• W1489659488 cites W1991112973 @default.
• W1489659488 cites W1993383767 @default.
• W1489659488 cites W1995732138 @default.
• W1489659488 cites W1997041104 @default.
• W1489659488 cites W2003660859 @default.
• W1489659488 cites W2005401205 @default.
• W1489659488 cites W2005843451 @default.
• W1489659488 cites W2007958340 @default.
• W1489659488 cites W2014247667 @default.
• W1489659488 cites W2015723183 @default.
• W1489659488 cites W2020081833 @default.
• W1489659488 cites W2027343672 @default.
• W1489659488 cites W2027408247 @default.
• W1489659488 cites W2030658423 @default.
• W1489659488 cites W2035772214 @default.
• W1489659488 cites W2043929927 @default.
• W1489659488 cites W2047723975 @default.
• W1489659488 cites W2049079467 @default.
• W1489659488 cites W2074228244 @default.
• W1489659488 cites W2081080176 @default.
• W1489659488 cites W2107921073 @default.
• W1489659488 cites W2119292856 @default.
• W1489659488 cites W2124530399 @default.
• W1489659488 cites W2136620829 @default.
• W1489659488 cites W2143981217 @default.
• W1489659488 cites W2150981663 @default.
• W1489659488 cites W2161714667 @default.
• W1489659488 cites W2163864506 @default.
• W1489659488 cites W2165489503 @default.
• W1489659488 doi "https://doi.org/10.1002/9783527636402.ch20" @default.
• W1489659488 hasPublicationYear "2011" @default.
• W1489659488 type Work @default.
• W1489659488 sameAs 1489659488 @default.
• W1489659488 citedByCount "0" @default.
• W1489659488 crossrefType "other" @default.
• W1489659488 hasAuthorship W1489659488A5007867266 @default.
• W1489659488 hasAuthorship W1489659488A5018366869 @default.
• W1489659488 hasAuthorship W1489659488A5037417242 @default.
• W1489659488 hasAuthorship W1489659488A5042897875 @default.
• W1489659488 hasConcept C107872376 @default.
• W1489659488 hasConcept C138885662 @default.
• W1489659488 hasConcept C142724271 @default.
• W1489659488 hasConcept C151730666 @default.
• W1489659488 hasConcept C161790260 @default.
• W1489659488 hasConcept C175156509 @default.
• W1489659488 hasConcept C179926584 @default.
• W1489659488 hasConcept C185592680 @default.
• W1489659488 hasConcept C199360897 @default.
• W1489659488 hasConcept C204787440 @default.
• W1489659488 hasConcept C2777777548 @default.
• W1489659488 hasConcept C2780497538 @default.
• W1489659488 hasConcept C3044715 @default.
• W1489659488 hasConcept C41008148 @default.
• W1489659488 hasConcept C41895202 @default.
• W1489659488 hasConcept C43369102 @default.
• W1489659488 hasConcept C523546767 @default.
• W1489659488 hasConcept C54355233 @default.
• W1489659488 hasConcept C55493867 @default.
• W1489659488 hasConcept C71924100 @default.
• W1489659488 hasConcept C86803240 @default.
• W1489659488 hasConceptScore W1489659488C107872376 @default.
• W1489659488 hasConceptScore W1489659488C138885662 @default.
• W1489659488 hasConceptScore W1489659488C142724271 @default.
• W1489659488 hasConceptScore W1489659488C151730666 @default.
• W1489659488 hasConceptScore W1489659488C161790260 @default.
• W1489659488 hasConceptScore W1489659488C175156509 @default.
• W1489659488 hasConceptScore W1489659488C179926584 @default.
• W1489659488 hasConceptScore W1489659488C185592680 @default.
• W1489659488 hasConceptScore W1489659488C199360897 @default.
• W1489659488 hasConceptScore W1489659488C204787440 @default.
• W1489659488 hasConceptScore W1489659488C2777777548 @default.
• W1489659488 hasConceptScore W1489659488C2780497538 @default.
• W1489659488 hasConceptScore W1489659488C3044715 @default.
• W1489659488 hasConceptScore W1489659488C41008148 @default.
• W1489659488 hasConceptScore W1489659488C41895202 @default.
• W1489659488 hasConceptScore W1489659488C43369102 @default.
• W1489659488 hasConceptScore W1489659488C523546767 @default.
• W1489659488 hasConceptScore W1489659488C54355233 @default.
• W1489659488 hasConceptScore W1489659488C55493867 @default.
• W1489659488 hasConceptScore W1489659488C71924100 @default.

• next