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- W1489716217 abstract "Publisher Summary This chapter describes novel glycosylated cationic liposomes, consisting of a glycosylated cationic cholesterol derivative and several helper lipids, which increase the transfection efficiency to cells possessing the corresponding receptors, such as hepatocytes and macrophages. Glycosylated cationic liposomes are possible candidates for cell-specific nonviral vectors by means of a receptor-mediated mechanism, although their cell specificity and transfection efficiency need further improvement. The preparation of glycosylated liposomes is much easier than that of asialoglycoproteins as targeting ligands for liposomes may be less immunogenic. These glycosylated liposomes can be applied not only to gene delivery but also to targeted delivery of conventional drugs, such as prostaglandin E1 and probucol. Different criteria for the preparation of glycosylated liposomes are required to obtain efficient drug delivery." @default.
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- W1489716217 date "2003-01-01" @default.
- W1489716217 modified "2023-10-06" @default.
- W1489716217 title "Glycosylated Cationic Liposomes for Carbohydrate Receptor–Mediated Gene Transfer" @default.
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- W1489716217 doi "https://doi.org/10.1016/s0076-6879(03)73025-0" @default.
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