Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489736338> ?p ?o ?g. }
- W1489736338 endingPage "67" @default.
- W1489736338 startingPage "859" @default.
- W1489736338 abstract "Whole-cell patch-clamp recordings were made from substantia gelatinosa (SG) neurons in thick adult rat transverse spinal cord slices with attached dorsal roots to study changes in fast synaptic transmission induced by peripheral inflammation. In slices from naive rats, primary afferent stimulation at Abeta fiber intensity elicited polysynaptic EPSCs in only 14 of 57 (25%) SG neurons. In contrast, Abeta fiber stimulation evoked polysynaptic EPSCs in 39 of 62 (63%) SG neurons recorded in slices from rats inflamed by an intraplantar injection of complete Freund's adjuvant (CFA) 48 hr earlier (p < 0.001). Although the peripheral inflammation had no significant effect on the threshold and conduction velocities of Abeta, Adelta, and C fibers recorded in dorsal roots, the mean threshold intensity for eliciting EPSCs was significantly lower in cells recorded from rats with inflammation (naive: 33.2 +/- 15.1 microA, n = 57; inflamed: 22.8 +/- 11.3 microA, n = 62, p < 0.001), and the mean latency of EPSCs elicited by Abeta fiber stimulation in CFA-treated rats was significantly shorter than that recorded from naive rats (3.3 +/- 1.8 msec, n = 36 vs 6.0 +/- 3.5 msec, n = 12; p = 0.010). Abeta fiber stimulation evoked polysynaptic IPSCs in 4 of 25 (16%) cells recorded from naive rat preparations and 14 of 26 (54%) SG neurons from CFA-treated rats (p < 0.001). The mean threshold intensity for IPSCs was also significantly lower in CFA-treated rats (naive: 32.5 +/- 15.7 microA, n = 25; inflamed: 21. 9 +/- 9.9 microA, n = 26, p = 0.013). The facilitation of Abeta fiber-mediated input into the substantia gelatinosa after peripheral inflammation may contribute to altered sensory processing." @default.
- W1489736338 created "2016-06-24" @default.
- W1489736338 creator A5004250030 @default.
- W1489736338 creator A5017534594 @default.
- W1489736338 creator A5066424797 @default.
- W1489736338 date "1999-01-15" @default.
- W1489736338 modified "2023-10-17" @default.
- W1489736338 title "Peripheral inflammation facilitates Abeta fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord." @default.
- W1489736338 cites W1482813429 @default.
- W1489736338 cites W1537638589 @default.
- W1489736338 cites W1600198752 @default.
- W1489736338 cites W1603496942 @default.
- W1489736338 cites W1766121781 @default.
- W1489736338 cites W1782765374 @default.
- W1489736338 cites W1888199791 @default.
- W1489736338 cites W1965711047 @default.
- W1489736338 cites W1974670594 @default.
- W1489736338 cites W1983542297 @default.
- W1489736338 cites W1991550485 @default.
- W1489736338 cites W1992398710 @default.
- W1489736338 cites W1993877941 @default.
- W1489736338 cites W1994618304 @default.
- W1489736338 cites W1999483556 @default.
- W1489736338 cites W2001026574 @default.
- W1489736338 cites W2002118416 @default.
- W1489736338 cites W2007211163 @default.
- W1489736338 cites W2009318457 @default.
- W1489736338 cites W2013519188 @default.
- W1489736338 cites W2019382248 @default.
- W1489736338 cites W2022317103 @default.
- W1489736338 cites W2022898812 @default.
- W1489736338 cites W2026186914 @default.
- W1489736338 cites W2036793236 @default.
- W1489736338 cites W2037184775 @default.
- W1489736338 cites W2042847772 @default.
- W1489736338 cites W2046593983 @default.
- W1489736338 cites W2048920146 @default.
- W1489736338 cites W2049485650 @default.
- W1489736338 cites W2051337621 @default.
- W1489736338 cites W2058687743 @default.
- W1489736338 cites W2064319342 @default.
- W1489736338 cites W2067825805 @default.
- W1489736338 cites W2071715974 @default.
- W1489736338 cites W2076068956 @default.
- W1489736338 cites W2080211618 @default.
- W1489736338 cites W2115568736 @default.
- W1489736338 cites W2132829674 @default.
- W1489736338 cites W2133743917 @default.
- W1489736338 cites W2345257840 @default.
- W1489736338 cites W2411384047 @default.
- W1489736338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782212" @default.
- W1489736338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9880605" @default.
- W1489736338 hasPublicationYear "1999" @default.
- W1489736338 type Work @default.
- W1489736338 sameAs 1489736338 @default.
- W1489736338 citedByCount "62" @default.
- W1489736338 countsByYear W14897363382012 @default.
- W1489736338 countsByYear W14897363382013 @default.
- W1489736338 countsByYear W14897363382014 @default.
- W1489736338 countsByYear W14897363382015 @default.
- W1489736338 countsByYear W14897363382016 @default.
- W1489736338 countsByYear W14897363382017 @default.
- W1489736338 countsByYear W14897363382018 @default.
- W1489736338 countsByYear W14897363382021 @default.
- W1489736338 countsByYear W14897363382022 @default.
- W1489736338 countsByYear W14897363382023 @default.
- W1489736338 crossrefType "journal-article" @default.
- W1489736338 hasAuthorship W1489736338A5004250030 @default.
- W1489736338 hasAuthorship W1489736338A5017534594 @default.
- W1489736338 hasAuthorship W1489736338A5066424797 @default.
- W1489736338 hasConcept C112592302 @default.
- W1489736338 hasConcept C126322002 @default.
- W1489736338 hasConcept C134018914 @default.
- W1489736338 hasConcept C15490471 @default.
- W1489736338 hasConcept C169760540 @default.
- W1489736338 hasConcept C170493617 @default.
- W1489736338 hasConcept C17077164 @default.
- W1489736338 hasConcept C185592680 @default.
- W1489736338 hasConcept C24998067 @default.
- W1489736338 hasConcept C2776914184 @default.
- W1489736338 hasConcept C2780775167 @default.
- W1489736338 hasConcept C46762472 @default.
- W1489736338 hasConcept C71924100 @default.
- W1489736338 hasConcept C86803240 @default.
- W1489736338 hasConceptScore W1489736338C112592302 @default.
- W1489736338 hasConceptScore W1489736338C126322002 @default.
- W1489736338 hasConceptScore W1489736338C134018914 @default.
- W1489736338 hasConceptScore W1489736338C15490471 @default.
- W1489736338 hasConceptScore W1489736338C169760540 @default.
- W1489736338 hasConceptScore W1489736338C170493617 @default.
- W1489736338 hasConceptScore W1489736338C17077164 @default.
- W1489736338 hasConceptScore W1489736338C185592680 @default.
- W1489736338 hasConceptScore W1489736338C24998067 @default.
- W1489736338 hasConceptScore W1489736338C2776914184 @default.
- W1489736338 hasConceptScore W1489736338C2780775167 @default.
- W1489736338 hasConceptScore W1489736338C46762472 @default.
- W1489736338 hasConceptScore W1489736338C71924100 @default.
- W1489736338 hasConceptScore W1489736338C86803240 @default.