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- W1489744377 abstract "Publisher SummaryA common theme in disease is death of cells. In diseases ranging from stroke to congestive heart disease to alcoholic cirrhosis of the liver, death of individual cells leads to irreversible functional loss in whole organs and ultimately mortality. For such diseases, prevention of cell death becomes a basic therapeutic goal. By contrast in neoplasia, the purpose of chemotherapy is to kill proliferating cancer cells. For either therapeutic goal, understanding the mechanisms of cell death becomes paramount. Although many stresses and stimuli cause cell death, the mode of cell death typically follows one of two patterns. The first is necrosis, a pathological term referring to areas of dead cells within a tissue or organ. Necrosis is typically the result of an acute and usually profound metabolic disruption, such as ischemia/reperfusion and severe toxicant-induced damage. The second pattern is programmed cell death, most commonly manifested as apoptosis. In apoptosis, specific stimuli initiate execution of well-defined pathways leading to orderly resorption of individual cells with minimal leakage of cellular components into the extracellular space and little inflammation. Apoptosis and necrosis are prominent events in pathogenesis. An understanding of cell death mechanisms forms the basis for effective interventions to either prevent cell death as a cause of disease or promote cell death in cancer chemotherapy." @default.
- W1489744377 created "2016-06-24" @default.
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- W1489744377 date "2010-01-01" @default.
- W1489744377 modified "2023-09-23" @default.
- W1489744377 title "Molecular Mechanisms of Cell Death" @default.
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- W1489744377 doi "https://doi.org/10.1016/b978-0-12-374418-0.00001-3" @default.
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