Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489746693> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1489746693 endingPage "358" @default.
- W1489746693 startingPage "353" @default.
- W1489746693 abstract "Abstract The low molecular weight compound L-tyrosine-azobenzenearsonate (RAT) induced immunity in guinea pigs, as evidenced by delayed cutaneous hypersensitivity and stimulation of DNA synthesis by lymphoid cells in culture. Two different conjugates of RAT and a poly-γ-D-glutamic acid hapten of m.w. 35,000 were prepared. In one, an average of nine molecules of RAT were linked directly to the PGA backbone [PGA-(RAT)9]. In the other, RAT was joined to PGA by means of 6-aminocaproyl (SAC) hydrocarbon chains that extended the RAT groups out from the PGA backbone by a maximum of 10 Å [PGA-(SAC-RAT)12]. Immunization with the two conjugates gave rise to anti-PGA antibody, PGA-(SAC-RAT)12 being somewhat more effective in that regard, and all animals developed delayed hypersensitivity to RAT but not to PGA. Lymphoid cells from animals sensitized to PGA-RAT conjugates demonstrated specificity for the homologous conjugates, assessed by the rate of incorporation of 14C-thymidine into DNA. Prior immunization with RAT potentiated the response to PGA following administration of the conjugates. Thus, it appears that a molecule with an m.w. of about 400 was recognized by antigenreactive cells and could serve as a carrier for a hapten with an m.w. of 35,000." @default.
- W1489746693 created "2016-06-24" @default.
- W1489746693 creator A5000609644 @default.
- W1489746693 creator A5018441520 @default.
- W1489746693 creator A5024583995 @default.
- W1489746693 date "1971-08-01" @default.
- W1489746693 modified "2023-10-09" @default.
- W1489746693 title "Antigen Recognition and the Immune Response: the Capacity of L-Tyrosine-Azobenzenearsonate to Serve as a Carrier for a Macromolecular Hapten" @default.
- W1489746693 doi "https://doi.org/10.4049/jimmunol.107.2.353" @default.
- W1489746693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4254973" @default.
- W1489746693 hasPublicationYear "1971" @default.
- W1489746693 type Work @default.
- W1489746693 sameAs 1489746693 @default.
- W1489746693 citedByCount "55" @default.
- W1489746693 countsByYear W14897466932017 @default.
- W1489746693 crossrefType "journal-article" @default.
- W1489746693 hasAuthorship W1489746693A5000609644 @default.
- W1489746693 hasAuthorship W1489746693A5018441520 @default.
- W1489746693 hasAuthorship W1489746693A5024583995 @default.
- W1489746693 hasBestOaLocation W14897466931 @default.
- W1489746693 hasConcept C134018914 @default.
- W1489746693 hasConcept C134306372 @default.
- W1489746693 hasConcept C147483822 @default.
- W1489746693 hasConcept C153911025 @default.
- W1489746693 hasConcept C159654299 @default.
- W1489746693 hasConcept C185592680 @default.
- W1489746693 hasConcept C197336794 @default.
- W1489746693 hasConcept C203014093 @default.
- W1489746693 hasConcept C24998067 @default.
- W1489746693 hasConcept C2776165026 @default.
- W1489746693 hasConcept C2778815084 @default.
- W1489746693 hasConcept C2780801004 @default.
- W1489746693 hasConcept C29144244 @default.
- W1489746693 hasConcept C33923547 @default.
- W1489746693 hasConcept C552990157 @default.
- W1489746693 hasConcept C55493867 @default.
- W1489746693 hasConcept C64241487 @default.
- W1489746693 hasConcept C86803240 @default.
- W1489746693 hasConcept C8891405 @default.
- W1489746693 hasConceptScore W1489746693C134018914 @default.
- W1489746693 hasConceptScore W1489746693C134306372 @default.
- W1489746693 hasConceptScore W1489746693C147483822 @default.
- W1489746693 hasConceptScore W1489746693C153911025 @default.
- W1489746693 hasConceptScore W1489746693C159654299 @default.
- W1489746693 hasConceptScore W1489746693C185592680 @default.
- W1489746693 hasConceptScore W1489746693C197336794 @default.
- W1489746693 hasConceptScore W1489746693C203014093 @default.
- W1489746693 hasConceptScore W1489746693C24998067 @default.
- W1489746693 hasConceptScore W1489746693C2776165026 @default.
- W1489746693 hasConceptScore W1489746693C2778815084 @default.
- W1489746693 hasConceptScore W1489746693C2780801004 @default.
- W1489746693 hasConceptScore W1489746693C29144244 @default.
- W1489746693 hasConceptScore W1489746693C33923547 @default.
- W1489746693 hasConceptScore W1489746693C552990157 @default.
- W1489746693 hasConceptScore W1489746693C55493867 @default.
- W1489746693 hasConceptScore W1489746693C64241487 @default.
- W1489746693 hasConceptScore W1489746693C86803240 @default.
- W1489746693 hasConceptScore W1489746693C8891405 @default.
- W1489746693 hasIssue "2" @default.
- W1489746693 hasLocation W14897466931 @default.
- W1489746693 hasLocation W14897466932 @default.
- W1489746693 hasOpenAccess W1489746693 @default.
- W1489746693 hasPrimaryLocation W14897466931 @default.
- W1489746693 hasRelatedWork W1507849322 @default.
- W1489746693 hasRelatedWork W1976832055 @default.
- W1489746693 hasRelatedWork W1990058423 @default.
- W1489746693 hasRelatedWork W1998243115 @default.
- W1489746693 hasRelatedWork W2028133140 @default.
- W1489746693 hasRelatedWork W2037496905 @default.
- W1489746693 hasRelatedWork W2044309065 @default.
- W1489746693 hasRelatedWork W2063245208 @default.
- W1489746693 hasRelatedWork W2395449481 @default.
- W1489746693 hasRelatedWork W4313309038 @default.
- W1489746693 hasVolume "107" @default.
- W1489746693 isParatext "false" @default.
- W1489746693 isRetracted "false" @default.
- W1489746693 magId "1489746693" @default.
- W1489746693 workType "article" @default.