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• W1489751440 abstract "There is not much hope for the solution of the problem of the action of radiation on tissues for some years. We know far too little about the physiology and chemistry of the individual cells and their interactions. The immediate action of radiation takes place inside the cell, and how can we expect to find out what happens in it when we know so little about its structure. Radiation, however, has given us a new method of studying changes inside the cells. It is important that we make it clear to ourselves what facts have been established, how these facts can be coordinated with the new theories, and which theories will be of any value to us. There are several theories concerning the action of radiation on tissues and it might be conceived that all must be wrong except, eventually, one. That is not necessary, however, as there are theories for different stages of the action which do not contradict each other but which can be combined very well. It is important, therefore, to consider the theories for each stage separately. Naturally we would like to know the complete chain of actions and are therefore led at first to consider the physical foundation and theories connected with it. All physicists now agree that all radiation used in therapy, except the particles from radioactive substances, consists of electromagnetic waves. That means some kind of vibrations transplanted through space. It is easier to visualize this by thinking of some substance which is set in vibration. Perhaps the simplest picture is a smooth water surface on which a stone is dropped. Several waves start where the stone hits the water and spread out one after the other with a certain constant speed over the surface. The distance from one top to the next is the wavelength. The difference between light and X-rays is simply a difference in wavelengths; the light waves are much longer than the X-rays (about 10,000 times longer). The visible part (light) lies between 3500 and 8000 A., whereas X-rays used in therapy cover the region 0.06 to 1 A. X-rays are harder or more penetrating the shorter the wavelengths; likewise the higher the voltage used, the shorter the wavelength." @default.
• W1489751440 created "2016-06-24" @default.
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• W1489751440 date "1925-06-01" @default.
• W1489751440 modified "2023-09-26" @default.
• W1489751440 title "Review of Theories of Mechanism of Action of Radiation in Treatment of Cancer" @default.
• W1489751440 doi "https://doi.org/10.1158/jcr.1925.190" @default.
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