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- W1489752929 endingPage "4967" @default.
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- W1489752929 abstract "Germinal centres are areas of intense B lymphocyte proliferation inside primary B cell follicles in spleen and lymph nodes. Rearranged V genes from single human B cells, isolated from histological sections of two such structures by micromanipulation, were amplified and sequenced. Cells from the follicular mantle were clonally diverse and largely expressed germline V genes. Germinal centres were dominated by a few large B cell clones dispersed throughout these structures and exhibiting intraclonal diversity by ongoing somatic hypermutation. Pronounced counterselection of replacement mutations seen in one of the germinal centres may indicate a late phase of the germinal centre reaction. A polyclonal population of activated B cells expressing unmutated antibodies in the dark zone of the other germinal centre may represent the initial founder cells." @default.
- W1489752929 created "2016-06-24" @default.
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- W1489752929 date "1993-12-01" @default.
- W1489752929 modified "2023-10-16" @default.
- W1489752929 title "Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections." @default.
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- W1489752929 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06189.x" @default.
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