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• W1489754482 abstract "This chapter describes the use of zebrafish in the study of hematopoiesis and stem cells, current research and emerging technology. Due to their size, optical clarity of the embryo and ease of genetic manipulation, zebrafish are ideal for chemical and genetic studies. Zebrafish blood development and the work of transcription factors have been thoroughly characterized allowing for numerous genetic studies. Large-scale forward genetic screens have led to the discovery of mutations in both hematopoietic development and that mimic human disease pathways. Chemical screens have been conducted on embryos leading to the discovery of biologically active compounds, which have been accepted for human drug trials. Advancements in transplantation including creating histocompatible lines of fish have increased understanding of stem cell behavior." @default.
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• W1489754482 date "2009-01-01" @default.
• W1489754482 modified "2023-10-14" @default.
• W1489754482 title "Zebrafish and Stem Cell Research" @default.
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• W1489754482 doi "https://doi.org/10.1016/b978-0-12-374729-7.00052-4" @default.
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