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- W1489774494 abstract "The last few years has seen a rapid increase in the use of surface enhanced laser desorption ionisation–time of flight (SELDI, SELDI-TOF) mass spectrometry, at the core of which are ProteinChip arrays, to search for biomarkers of infectious disease. Reasons include the greater reproducibility of current technology (instrument and ProteinChip arrays), the availability of increasingly powerful analytical tools and the appreciation of confounding variables (e.g. sample preparation and study design). Biomarkers have been sought for diagnosis of infection, disease progression, prediction of those at high risk from other disease as the result of infection (e.g. cancer) and to increase understanding of infectious disease processes. SELDI has been used for biomarker discovery in humans and animals as a result of infection by bacteria, viruses and parasites. The molecular identification of the discriminatory peptides/proteins allows the development or utilisation of cheaper simpler tests such as ELISAs. In some instances, SELDI has been used to measure biomarkers for infectious disease where conventional tests are unavailable or of insufficient sensitivity and specificity. It is likely that there will be increased use of SELDI, particularly if it is combined with parallel developments in sample preparation, allowing the detection of less abundant and potentially more informative peptides/proteins." @default.
- W1489774494 created "2016-06-24" @default.
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- W1489774494 date "2010-06-15" @default.
- W1489774494 modified "2023-10-18" @default.
- W1489774494 title "Microbial Disease Biomarkers Using ProteinChip Arrays" @default.
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- W1489774494 doi "https://doi.org/10.1002/9780470665497.ch11" @default.
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