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- W1489775030 abstract "This review focuses on the spliced leader (SL) RNA and uridylic acid-rich small nuclear RNAs (U-snRNAs) involved in pre-mRNA processing in trypanosomatid protozoa, with particular emphasis on the mechanism of transcription and cap formation. The SL RNA plays a central role in mRNA biogenesis by providing the unique cap 4 structure to the 5' end of all mRNAs by trans-splicing. The trimethylguanosine capped U-snRNAs, on the other hand, represent an unusual example among eukaryotic snRNAs in that they are transcribed by RNA polymerase III. This implies the existence of a distinctive mechanism for capping enzyme selection by the transcriptional machinery. Furthermore, the transcription units of U-snRNA genes offer yet another example of the variety of choices that have been established during eukaryotic evolution, namely that an upstream tRNA gene or tRNA-like gene provides extragenic promoter elements for a downstream small RNA gene." @default.
- W1489775030 created "2016-06-24" @default.
- W1489775030 creator A5030887593 @default.
- W1489775030 creator A5062725977 @default.
- W1489775030 date "2002-01-01" @default.
- W1489775030 modified "2023-09-23" @default.
- W1489775030 title "Unconventional rules of small nuclear RNA transcription and cap modification in trypanosomatids." @default.
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- W1489775030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5977529" @default.
- W1489775030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11868986" @default.
- W1489775030 hasPublicationYear "2002" @default.
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