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- W1489777963 abstract "Abstract The initial discovery of adeno-associated virus (AAV) mixed with adenovirus particles was not a fortuitous one but rather an expression of AAV biology. Indeed, as it came to be known, in addition to the unavoidable host cell, AAV typically needs a so-called helper virus such as adenovirus to replicate. Since the AAV life cycle revolves around another unrelated virus it was dubbed a satellite virus. However, the structural simplicity plus the defective and non-pathogenic character of this satellite virus caused recombinant forms to acquire centre-stage prominence in the current constellation of vectors for human gene therapy. In the present review, issues related to the development of recombinant AAV (rAAV) vectors, from the general principle to production methods, tropism modifications and other emerging technologies are discussed. In addition, the accumulating knowledge regarding the mechanisms of rAAV genome transduction and persistence is reviewed. The topics on rAAV vectorology are supplemented with information on the parental virus biology with an emphasis on aspects that directly impact on vector design and performance such as genome replication, genetic structure, and host cell entry." @default.
- W1489777963 created "2016-06-24" @default.
- W1489777963 creator A5046092001 @default.
- W1489777963 date "2005-05-06" @default.
- W1489777963 modified "2023-10-17" @default.
- W1489777963 title "Adeno-associated virus: from defective virus to effective vector" @default.
- W1489777963 cites W1487084354 @default.
- W1489777963 cites W1500537600 @default.
- W1489777963 cites W1505196125 @default.
- W1489777963 cites W1541189153 @default.
- W1489777963 cites W1542198680 @default.
- W1489777963 cites W1544405851 @default.
- W1489777963 cites W1554330891 @default.
- W1489777963 cites W1565788467 @default.
- W1489777963 cites W1573172871 @default.
- W1489777963 cites W1588659566 @default.
- W1489777963 cites W1594355808 @default.
- W1489777963 cites W1597426364 @default.
- W1489777963 cites W1755517856 @default.
- W1489777963 cites W1756236371 @default.
- W1489777963 cites W1824389368 @default.
- W1489777963 cites W1879335341 @default.
- W1489777963 cites W1901002830 @default.
- W1489777963 cites W1912028323 @default.
- W1489777963 cites W1945342395 @default.
- W1489777963 cites W1964241088 @default.
- W1489777963 cites W1965786463 @default.
- W1489777963 cites W1966493859 @default.
- W1489777963 cites W1966570731 @default.
- W1489777963 cites W1968006472 @default.
- W1489777963 cites W1968245246 @default.
- W1489777963 cites W1968382713 @default.
- W1489777963 cites W1968912221 @default.
- W1489777963 cites W1973395544 @default.
- W1489777963 cites W1987453834 @default.
- W1489777963 cites W1987546088 @default.
- W1489777963 cites W2000185853 @default.
- W1489777963 cites W2000217017 @default.
- W1489777963 cites W2001738143 @default.
- W1489777963 cites W2002489396 @default.
- W1489777963 cites W2004771840 @default.
- W1489777963 cites W2010065280 @default.
- W1489777963 cites W2010126361 @default.
- W1489777963 cites W2015426350 @default.
- W1489777963 cites W2016782363 @default.
- W1489777963 cites W2017608179 @default.
- W1489777963 cites W2018908952 @default.
- W1489777963 cites W2019612944 @default.
- W1489777963 cites W2019814860 @default.
- W1489777963 cites W2026854040 @default.
- W1489777963 cites W2027339842 @default.
- W1489777963 cites W2028043537 @default.
- W1489777963 cites W2041225014 @default.
- W1489777963 cites W2045242923 @default.
- W1489777963 cites W2046401175 @default.
- W1489777963 cites W2047608515 @default.
- W1489777963 cites W2049958940 @default.
- W1489777963 cites W2050289194 @default.
- W1489777963 cites W2050532629 @default.
- W1489777963 cites W2051072233 @default.
- W1489777963 cites W2051442157 @default.
- W1489777963 cites W205267551 @default.
- W1489777963 cites W2056602419 @default.
- W1489777963 cites W2059108053 @default.
- W1489777963 cites W2059202997 @default.
- W1489777963 cites W2060216304 @default.
- W1489777963 cites W2061694709 @default.
- W1489777963 cites W2062249345 @default.
- W1489777963 cites W2062622002 @default.
- W1489777963 cites W2066015597 @default.
- W1489777963 cites W2067189573 @default.
- W1489777963 cites W2070082633 @default.
- W1489777963 cites W2079895559 @default.
- W1489777963 cites W2081064825 @default.
- W1489777963 cites W2082583103 @default.
- W1489777963 cites W2084080175 @default.
- W1489777963 cites W2085778900 @default.
- W1489777963 cites W2086683565 @default.
- W1489777963 cites W2087396336 @default.
- W1489777963 cites W2088555526 @default.
- W1489777963 cites W2090650873 @default.
- W1489777963 cites W2092806325 @default.
- W1489777963 cites W2096289466 @default.
- W1489777963 cites W2096466927 @default.
- W1489777963 cites W2100405455 @default.
- W1489777963 cites W2101605345 @default.
- W1489777963 cites W2103928212 @default.
- W1489777963 cites W2109152260 @default.
- W1489777963 cites W2109751467 @default.
- W1489777963 cites W2113444875 @default.
- W1489777963 cites W2113637218 @default.
- W1489777963 cites W2114865184 @default.
- W1489777963 cites W2115185064 @default.
- W1489777963 cites W2119164964 @default.
- W1489777963 cites W2120066089 @default.
- W1489777963 cites W2120683337 @default.
- W1489777963 cites W2121034113 @default.
- W1489777963 cites W2122632939 @default.
- W1489777963 cites W2122637604 @default.
- W1489777963 cites W2126012630 @default.