FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489790004> ?p ?o ?g. }

• W1489790004 endingPage "951" @default.
• W1489790004 startingPage "943" @default.
• W1489790004 abstract "Glioblastoma multiforme (GBM), a tumor associated with poor prognosis, is known to be resistant to radiotherapy and alkylating agents such as temozolomide (TMZ). β-elemene, a monomer found in Chinese traditional herbs extracted from Curcuma wenyujin, is currently being used as an antitumor drug for different types of tumors including GBM. In the present study, we investigated the roles of β-elemene in the radiosensitivity and chemosensitivity of GBM cells. Human GBM cell lines U87-MG, T98G, U251, LN229 and rat C6 cells were treated with β-elemene combined with radiation or TMZ. We used MTT and colony forming assays to evaluate the proliferation and survival of the cells, and the comet assay to observe DNA damage. Expression of proteins was analyzed by immunoblotting. In the present study, we found that β-elemene inhibited the proliferation and survival of different GBM cell lines when combined with radiotherapy or TMZ via inhibition of DNA damage repair. Treatment of GBM cells with β-elemene decreased the phosphorylation of ataxia telangiectasia mutated (ATM), AKT and ERK following radiotherapy or chemotherapy. These results revealed that β-elemene could significantly increase the radiosensitivity and chemosensitivity of GBM. β-elemene may be used as a potential drug in combination with the radiotherapy and chemotherapy of GBM." @default.
• W1489790004 created "2016-06-24" @default.
• W1489790004 creator A5002034669 @default.
• W1489790004 creator A5060989813 @default.
• W1489790004 creator A5085081570 @default.
• W1489790004 creator A5089330380 @default.
• W1489790004 date "2015-06-11" @default.
• W1489790004 modified "2023-10-12" @default.
• W1489790004 title "β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway" @default.
• W1489790004 cites W1967726440 @default.
• W1489790004 cites W1971873531 @default.
• W1489790004 cites W1977133926 @default.
• W1489790004 cites W1984647853 @default.
• W1489790004 cites W1987681742 @default.
• W1489790004 cites W1992783176 @default.
• W1489790004 cites W2003438982 @default.
• W1489790004 cites W2003601710 @default.
• W1489790004 cites W2007773961 @default.
• W1489790004 cites W2012909561 @default.
• W1489790004 cites W2039609784 @default.
• W1489790004 cites W2043737875 @default.
• W1489790004 cites W2047100770 @default.
• W1489790004 cites W2051758351 @default.
• W1489790004 cites W2068993487 @default.
• W1489790004 cites W2070019711 @default.
• W1489790004 cites W2074429674 @default.
• W1489790004 cites W2075124520 @default.
• W1489790004 cites W2093904762 @default.
• W1489790004 cites W2096024448 @default.
• W1489790004 cites W2099776053 @default.
• W1489790004 cites W2109050099 @default.
• W1489790004 cites W2120302274 @default.
• W1489790004 cites W2134457209 @default.
• W1489790004 cites W2139737762 @default.
• W1489790004 cites W2148977460 @default.
• W1489790004 cites W2154404543 @default.
• W1489790004 cites W2160382843 @default.
• W1489790004 cites W2161180058 @default.
• W1489790004 cites W2164049072 @default.
• W1489790004 doi "https://doi.org/10.3892/or.2015.4050" @default.
• W1489790004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26062577" @default.
• W1489790004 hasPublicationYear "2015" @default.
• W1489790004 type Work @default.
• W1489790004 sameAs 1489790004 @default.
• W1489790004 citedByCount "36" @default.
• W1489790004 countsByYear W14897900042016 @default.
• W1489790004 countsByYear W14897900042017 @default.
• W1489790004 countsByYear W14897900042018 @default.
• W1489790004 countsByYear W14897900042019 @default.
• W1489790004 countsByYear W14897900042020 @default.
• W1489790004 countsByYear W14897900042021 @default.
• W1489790004 countsByYear W14897900042022 @default.
• W1489790004 countsByYear W14897900042023 @default.
• W1489790004 crossrefType "journal-article" @default.
• W1489790004 hasAuthorship W1489790004A5002034669 @default.
• W1489790004 hasAuthorship W1489790004A5060989813 @default.
• W1489790004 hasAuthorship W1489790004A5085081570 @default.
• W1489790004 hasAuthorship W1489790004A5089330380 @default.
• W1489790004 hasBestOaLocation W14897900041 @default.
• W1489790004 hasConcept C126322002 @default.
• W1489790004 hasConcept C134935766 @default.
• W1489790004 hasConcept C143425029 @default.
• W1489790004 hasConcept C1491633281 @default.
• W1489790004 hasConcept C190283241 @default.
• W1489790004 hasConcept C206684579 @default.
• W1489790004 hasConcept C2776428644 @default.
• W1489790004 hasConcept C2777389519 @default.
• W1489790004 hasConcept C2778227246 @default.
• W1489790004 hasConcept C2780358455 @default.
• W1489790004 hasConcept C2780783641 @default.
• W1489790004 hasConcept C2781018059 @default.
• W1489790004 hasConcept C2781340500 @default.
• W1489790004 hasConcept C29537977 @default.
• W1489790004 hasConcept C502942594 @default.
• W1489790004 hasConcept C509974204 @default.
• W1489790004 hasConcept C552990157 @default.
• W1489790004 hasConcept C55493867 @default.
• W1489790004 hasConcept C62112901 @default.
• W1489790004 hasConcept C67082663 @default.
• W1489790004 hasConcept C71924100 @default.
• W1489790004 hasConcept C86803240 @default.
• W1489790004 hasConceptScore W1489790004C126322002 @default.
• W1489790004 hasConceptScore W1489790004C134935766 @default.
• W1489790004 hasConceptScore W1489790004C143425029 @default.
• W1489790004 hasConceptScore W1489790004C1491633281 @default.
• W1489790004 hasConceptScore W1489790004C190283241 @default.
• W1489790004 hasConceptScore W1489790004C206684579 @default.
• W1489790004 hasConceptScore W1489790004C2776428644 @default.
• W1489790004 hasConceptScore W1489790004C2777389519 @default.
• W1489790004 hasConceptScore W1489790004C2778227246 @default.
• W1489790004 hasConceptScore W1489790004C2780358455 @default.
• W1489790004 hasConceptScore W1489790004C2780783641 @default.
• W1489790004 hasConceptScore W1489790004C2781018059 @default.
• W1489790004 hasConceptScore W1489790004C2781340500 @default.
• W1489790004 hasConceptScore W1489790004C29537977 @default.
• W1489790004 hasConceptScore W1489790004C502942594 @default.
• W1489790004 hasConceptScore W1489790004C509974204 @default.
• W1489790004 hasConceptScore W1489790004C552990157 @default.

• next