FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489794034> ?p ?o ?g. }

• W1489794034 endingPage "267" @default.
• W1489794034 startingPage "258" @default.
• W1489794034 abstract "Background The prevalence of dyslipidaemia and the risk of cardiovascular disease are elevated in patients with type 2 diabetes. This analysis compared the effects of insulin glargine versus thiazolidinediones (TZDs) on lipid profiles. Methods Patient-level data were pooled from two randomized clinical studies. The population included 552 men and women aged >18 years, diagnosed with type 2 diabetes for at least 6 months, on metformin and/or sulphonylurea, and with A1C ≥7.5% and <12.0% at screening. Lipid outcome measures included change from baseline in lipid levels [low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol, triglycerides, and free fatty acids] and attainment of lipid goals for LDL-C, non-HDL-C, and triglycerides. Results Both insulin glargine and TZDs improved lipid profiles from baseline values. Compared with TZDs, treatment with insulin glargine led to 7.9% greater reduction in LDL-C (p < 0.0003), 7.5% greater reduction in non-HDL-C (p < 0.0001), and 7.8% greater reduction in total cholesterol (p < 0.0001), whereas the HDL-C increase with TZD was 7.6% greater than that with insulin glargine (p < 0.0001). The percentage of patients attaining the lipid goals was comparable between insulin glargine and pioglitazone, but lower for rosiglitazone. Insulin glargine improved glycaemic control more than TZDs; however, insulin glargine caused more hypoglycaemia. Treatment with TZDs caused more weight gain and peripheral oedema. Conclusion These findings suggest that the favourable effects of insulin glargine on plasma lipid profiles should be considered among the advantages of treatment with insulin glargine as they are for TZDs. Copyright © 2011 John Wiley & Sons, Ltd." @default.
• W1489794034 created "2016-06-24" @default.
• W1489794034 creator A5032877471 @default.
• W1489794034 creator A5037251074 @default.
• W1489794034 creator A5040283884 @default.
• W1489794034 creator A5045489578 @default.
• W1489794034 creator A5050076657 @default.
• W1489794034 creator A5057972528 @default.
• W1489794034 creator A5061286574 @default.
• W1489794034 creator A5080844321 @default.
• W1489794034 creator A5086589108 @default.
• W1489794034 date "2012-03-01" @default.
• W1489794034 modified "2023-09-27" @default.
• W1489794034 title "Comparing the effects of insulin glargine and thiazolidinediones on plasma lipids in type 2 diabetes: a patient‐level pooled analysis" @default.
• W1489794034 cites W1968319423 @default.
• W1489794034 cites W1968865647 @default.
• W1489794034 cites W1975019670 @default.
• W1489794034 cites W1982990554 @default.
• W1489794034 cites W1989600614 @default.
• W1489794034 cites W1994999237 @default.
• W1489794034 cites W1998637093 @default.
• W1489794034 cites W2005778725 @default.
• W1489794034 cites W2012435514 @default.
• W1489794034 cites W2021129858 @default.
• W1489794034 cites W2028933018 @default.
• W1489794034 cites W2039250890 @default.
• W1489794034 cites W2039401819 @default.
• W1489794034 cites W2052856694 @default.
• W1489794034 cites W2055416829 @default.
• W1489794034 cites W2088970881 @default.
• W1489794034 cites W2091863647 @default.
• W1489794034 cites W2097716578 @default.
• W1489794034 cites W2098838694 @default.
• W1489794034 cites W2102578670 @default.
• W1489794034 cites W2102675827 @default.
• W1489794034 cites W2104661418 @default.
• W1489794034 cites W2108038378 @default.
• W1489794034 cites W2116404316 @default.
• W1489794034 cites W2119356550 @default.
• W1489794034 cites W2122130517 @default.
• W1489794034 cites W2122596924 @default.
• W1489794034 cites W2154325287 @default.
• W1489794034 cites W2159969745 @default.
• W1489794034 cites W2167067204 @default.
• W1489794034 cites W2172170752 @default.
• W1489794034 cites W2172488527 @default.
• W1489794034 cites W2596624061 @default.
• W1489794034 cites W2975364463 @default.
• W1489794034 cites W4231676898 @default.
• W1489794034 cites W4238251256 @default.
• W1489794034 cites W4254261652 @default.
• W1489794034 doi "https://doi.org/10.1002/dmrr.1305" @default.
• W1489794034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380564" @default.
• W1489794034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22081557" @default.
• W1489794034 hasPublicationYear "2012" @default.
• W1489794034 type Work @default.
• W1489794034 sameAs 1489794034 @default.
• W1489794034 citedByCount "15" @default.
• W1489794034 countsByYear W14897940342012 @default.
• W1489794034 countsByYear W14897940342013 @default.
• W1489794034 countsByYear W14897940342014 @default.
• W1489794034 countsByYear W14897940342015 @default.
• W1489794034 countsByYear W14897940342016 @default.
• W1489794034 countsByYear W14897940342017 @default.
• W1489794034 countsByYear W14897940342019 @default.
• W1489794034 countsByYear W14897940342021 @default.
• W1489794034 crossrefType "journal-article" @default.
• W1489794034 hasAuthorship W1489794034A5032877471 @default.
• W1489794034 hasAuthorship W1489794034A5037251074 @default.
• W1489794034 hasAuthorship W1489794034A5040283884 @default.
• W1489794034 hasAuthorship W1489794034A5045489578 @default.
• W1489794034 hasAuthorship W1489794034A5050076657 @default.
• W1489794034 hasAuthorship W1489794034A5057972528 @default.
• W1489794034 hasAuthorship W1489794034A5061286574 @default.
• W1489794034 hasAuthorship W1489794034A5080844321 @default.
• W1489794034 hasAuthorship W1489794034A5086589108 @default.
• W1489794034 hasBestOaLocation W14897940341 @default.
• W1489794034 hasConcept C126322002 @default.
• W1489794034 hasConcept C134018914 @default.
• W1489794034 hasConcept C2777180221 @default.
• W1489794034 hasConcept C2778163477 @default.
• W1489794034 hasConcept C2778270857 @default.
• W1489794034 hasConcept C2778384471 @default.
• W1489794034 hasConcept C2779306644 @default.
• W1489794034 hasConcept C2779920387 @default.
• W1489794034 hasConcept C2780152017 @default.
• W1489794034 hasConcept C555293320 @default.
• W1489794034 hasConcept C71924100 @default.
• W1489794034 hasConceptScore W1489794034C126322002 @default.
• W1489794034 hasConceptScore W1489794034C134018914 @default.
• W1489794034 hasConceptScore W1489794034C2777180221 @default.
• W1489794034 hasConceptScore W1489794034C2778163477 @default.
• W1489794034 hasConceptScore W1489794034C2778270857 @default.
• W1489794034 hasConceptScore W1489794034C2778384471 @default.
• W1489794034 hasConceptScore W1489794034C2779306644 @default.
• W1489794034 hasConceptScore W1489794034C2779920387 @default.
• W1489794034 hasConceptScore W1489794034C2780152017 @default.
• W1489794034 hasConceptScore W1489794034C555293320 @default.

• next