FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489923641> ?p ?o ?g. }

• W1489923641 abstract "For research on the health risks of galactic cosmic rays (GCR) ground-based accelerators have been used for radiobiology research with mono-energetic beams of single high charge, Z and energy, E (HZE) particles. In this paper we consider the pros and cons of a GCR reference field at a particle accelerator. At the NASA Space Radiation Laboratory (NSRL) we have proposed a GCR simulator, which implements a new rapid switching mode and higher energy beam extraction to 1.5 GeV/u, in order to integrate multiple ions into a single simulation within hours or longer for chronic exposures. After considering the GCR environment and energy limitations of NSRL, we performed extensive simulation studies using the stochastic transport code, GERMcode (GCR Event Risk Model) to define a GCR reference field using 9 HZE particle beam-energy combinations each with a unique absorber thickness to provide fragmentation and 10 or more energies of proton and 4He beams. The reference field is shown to well represent the charge dependence of GCR dose in several energy bins behind shielding compared to a simulated GCR environment. However a more significant challenge for space radiobiology research is to consider chronic GCR exposure of up to 3 years in relation to simulations with animal models of human risks. We discuss issues in approaches to map important biological time scales in experimental models using ground-based simulation with extended exposure of up to a few weeks using chronic or fractionation exposures. A kinetics model of HZE particle hit probabilities suggests that experimental simulations of several weeks will be needed to avoid high fluence rate artifacts, which places limitations on the experiments to be performed. Ultimately risk estimates are limited by theoretical understanding, and focus on improving understanding of mechanisms and development of experimental models to improve this understanding should remain the highest priority for space radiobiology research." @default.
• W1489923641 created "2016-06-24" @default.
• W1489923641 creator A5043852381 @default.
• W1489923641 creator A5059239993 @default.
• W1489923641 creator A5085131349 @default.
• W1489923641 date "2015-06-04" @default.
• W1489923641 modified "2023-10-18" @default.
• W1489923641 title "Issues for Simulation of Galactic Cosmic Ray Exposures for Radiobiological Research at Ground-Based Accelerators" @default.
• W1489923641 cites W1481609997 @default.
• W1489923641 cites W1551593332 @default.
• W1489923641 cites W1968762101 @default.
• W1489923641 cites W1978127327 @default.
• W1489923641 cites W1980981554 @default.
• W1489923641 cites W1981648897 @default.
• W1489923641 cites W1982931175 @default.
• W1489923641 cites W1983553517 @default.
• W1489923641 cites W1985283713 @default.
• W1489923641 cites W1988066275 @default.
• W1489923641 cites W1988995172 @default.
• W1489923641 cites W1989190950 @default.
• W1489923641 cites W1993314127 @default.
• W1489923641 cites W2013459365 @default.
• W1489923641 cites W2032433540 @default.
• W1489923641 cites W2036429304 @default.
• W1489923641 cites W2037270620 @default.
• W1489923641 cites W2040050073 @default.
• W1489923641 cites W2043415528 @default.
• W1489923641 cites W2047259064 @default.
• W1489923641 cites W2048131957 @default.
• W1489923641 cites W2051493175 @default.
• W1489923641 cites W2053987315 @default.
• W1489923641 cites W2054851504 @default.
• W1489923641 cites W2055689755 @default.
• W1489923641 cites W2058058526 @default.
• W1489923641 cites W2061995059 @default.
• W1489923641 cites W2073875806 @default.
• W1489923641 cites W2075410218 @default.
• W1489923641 cites W2077922140 @default.
• W1489923641 cites W2085932935 @default.
• W1489923641 cites W2089423309 @default.
• W1489923641 cites W2091720192 @default.
• W1489923641 cites W2103461789 @default.
• W1489923641 cites W2118036703 @default.
• W1489923641 cites W2120810793 @default.
• W1489923641 cites W2124365311 @default.
• W1489923641 cites W2144078110 @default.
• W1489923641 cites W2148434747 @default.
• W1489923641 cites W2150738279 @default.
• W1489923641 cites W2156168145 @default.
• W1489923641 cites W2158160948 @default.
• W1489923641 cites W2164394925 @default.
• W1489923641 cites W2173229798 @default.
• W1489923641 cites W4318445336 @default.
• W1489923641 cites W4321429314 @default.
• W1489923641 doi "https://doi.org/10.3389/fonc.2015.00122" @default.
• W1489923641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4455530" @default.
• W1489923641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26090339" @default.
• W1489923641 hasPublicationYear "2015" @default.
• W1489923641 type Work @default.
• W1489923641 sameAs 1489923641 @default.
• W1489923641 citedByCount "42" @default.
• W1489923641 countsByYear W14899236412015 @default.
• W1489923641 countsByYear W14899236412016 @default.
• W1489923641 countsByYear W14899236412017 @default.
• W1489923641 countsByYear W14899236412018 @default.
• W1489923641 countsByYear W14899236412019 @default.
• W1489923641 countsByYear W14899236412020 @default.
• W1489923641 countsByYear W14899236412021 @default.
• W1489923641 countsByYear W14899236412022 @default.
• W1489923641 countsByYear W14899236412023 @default.
• W1489923641 crossrefType "journal-article" @default.
• W1489923641 hasAuthorship W1489923641A5043852381 @default.
• W1489923641 hasAuthorship W1489923641A5059239993 @default.
• W1489923641 hasAuthorship W1489923641A5085131349 @default.
• W1489923641 hasBestOaLocation W14899236411 @default.
• W1489923641 hasConcept C111309251 @default.
• W1489923641 hasConcept C111337013 @default.
• W1489923641 hasConcept C11928243 @default.
• W1489923641 hasConcept C121332964 @default.
• W1489923641 hasConcept C125118446 @default.
• W1489923641 hasConcept C153385146 @default.
• W1489923641 hasConcept C185544564 @default.
• W1489923641 hasConcept C19527891 @default.
• W1489923641 hasConcept C2265751 @default.
• W1489923641 hasConcept C2987978230 @default.
• W1489923641 hasConcept C30475298 @default.
• W1489923641 hasConcept C62520636 @default.
• W1489923641 hasConceptScore W1489923641C111309251 @default.
• W1489923641 hasConceptScore W1489923641C111337013 @default.
• W1489923641 hasConceptScore W1489923641C11928243 @default.
• W1489923641 hasConceptScore W1489923641C121332964 @default.
• W1489923641 hasConceptScore W1489923641C125118446 @default.
• W1489923641 hasConceptScore W1489923641C153385146 @default.
• W1489923641 hasConceptScore W1489923641C185544564 @default.
• W1489923641 hasConceptScore W1489923641C19527891 @default.
• W1489923641 hasConceptScore W1489923641C2265751 @default.
• W1489923641 hasConceptScore W1489923641C2987978230 @default.
• W1489923641 hasConceptScore W1489923641C30475298 @default.
• W1489923641 hasConceptScore W1489923641C62520636 @default.
• W1489923641 hasLocation W14899236411 @default.

• next