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- W1489927165 abstract "Abstract In previous studies with rats we observed that certain thrombogenic diets resulted in a stronger clot (greater binding power as measured in the thrombelastograph) and prolonged clot-lysis times as compared to simple stock diets. Furthermore, there was a close correlation between the plasma fibrinogen concentration and the binding power. In an attempt to investigate further the previously observed relationship between plasma fibrinogen and binding power, varying amounts of purified fibrinogen were added to plasma with normal fibrinogen levels, and the binding powers were measured in the thrombelastograph. It was found that the binding power was directly proportional to the fibrinogen concentration in the plasma. The experiment was carried out further to determine how early changes in various coagulation factors begin to take place after initiation of high-fat diets. Fibrinogen and prothrombin levels began to rise as early as within 1 week after the administration of high-fat diets. The changes were accompanied by a significant increase of serum cholesterol levels. By the 18th day prothrombin and fibrinogen concentrations doubled their control values, and the increase in serum cholesterol was more than tenfold." @default.
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- W1489927165 date "1964-06-01" @default.
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- W1489927165 title "Dietary lipids and thrombosis" @default.
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- W1489927165 doi "https://doi.org/10.1016/0014-4800(64)90056-5" @default.
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