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- W1489975978 endingPage "323" @default.
- W1489975978 startingPage "296" @default.
- W1489975978 abstract "This chapter addresses gross anatomy and physiology of the brain, and how physiological processes play a role in central nervous system (CNS) drug target site distribution. This is followed by a discussion on physiologically-based pharmacokinetic model (PBPK) characteristics. The chapter explains how PBPK models will have better translational predictive power for CNS target site distribution in humans, as it explicitly distinguishes between drug and system properties. Knowledge of human brain target site concentrations will then be useful for further development of PBPK-PD models in healthy and disease conditions, to further pave the way to predict the right drug at the right location, right time, and right concentrations. With the use of PBPK modeling approaches, the aim is to develop models with higher predictive power of CNS target site distribution in humans." @default.
- W1489975978 created "2016-06-24" @default.
- W1489975978 creator A5017208135 @default.
- W1489975978 date "2015-01-02" @default.
- W1489975978 modified "2023-09-26" @default.
- W1489975978 title "PBPK Modeling Approach for Predictions of Human CNS Drug Brain Distribution" @default.
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