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• W1490034459 abstract "In recent years it has become evident that mesenchymal stem cells (MSCs), also termed mesenchymal stromal cells, have potent immunomodulatory effects in addition to their known ability of organ regeneration and recruitment to sites of injured or inflamed tissue (Caplan 1991; Garin, Chu et al. 2007; Nauta and Fibbe 2007; Bianco, Robey et al. 2008; Shi, Hu et al. 2010). While the ability of MSCs to mediate tissue and organ repair replacing damaged tissue has initially been attributed to their multilineage differentiation potential, it is now widely attributed to their ability to home to site of injury secreting cytokines and growth factors that mediate the repair process inducing proliferation and differentiation of progenitor cells (Karp and Leng Teo 2009; Hoogduijn, Popp et al. 2010; Sordi, Melzi et al. 2010). Whether MSCs migrate from the bone marrow in case of injury or if the stem cell niche available in the diseased organ replaces dying cells remains to be elucidated. MSCs have been demonstrated to exhibit a profound immunomodulatory effect on T cells, B cells, and Natural Killer (NK) cells. This effect has been recently shown to be mediated via soluble factors, and this can be enhanced further if direct cell–cell contact between the MSCs and immune cells is allowed (Ren, Zhao et al. 2010). Via these factors, MSCs inhibit T cell proliferation (Di Nicola, Carlo-Stella et al. 2002; Aggarwal and Pittenger 2005), maturation and differentiation of B cells (Corcione, Benvenuto et al. 2006; Tabera, Perez-Simon et al. 2008; Asari, Itakura et al. 2009), maturation of dendritic cells (DCs) (Nauta, Kruisselbrink et al. 2006), generation of cytotoxic T cells (Angoulvant, Clerc et al. 2004) and proliferation and cytotoxic activity of NK cells (Rasmusson, Ringden et al. 2003; Sotiropoulou, Perez et al. 2006; Spaggiari, Capobianco et al. 2008), while inducing regulatory T cells (Tregs) (Prevosto, Zancolli et al. 2007; Di Ianni, Del Papa et al. 2008; Crop, Baan et al. 2010). MSCs have been shown to induce immunologic peripheral tolerance, suggesting their potential application in a therapeutic approach for immune mediated disorders. In this context, MSCs can be used to support the function of standard pharmacological immunosuppressants to reduce their dosage or even replace such toxic immunosuppressants promoting long-term survival of the transplanted organ (Crop, Baan et al. 2009)." @default.
• W1490034459 created "2016-06-24" @default.
• W1490034459 creator A5000584189 @default.
• W1490034459 creator A5030825449 @default.
• W1490034459 creator A5087828930 @default.
• W1490034459 date "2012-02-24" @default.
• W1490034459 modified "2023-10-17" @default.
• W1490034459 title "Mesenchymal Stem Cells as Immunomodulators in Transplantation" @default.
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