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- W1490061807 abstract "The 98 cases of squamous-cell epithelioma of the skin and lip under discussion have been previously studied and graded by Broders. They represent all of the patients treated surgically at the Mayo Clinic for squamous-cell epithelioma of the skin and lip between November 1, 1904, and July 22, 1915, who died from recurrence of the lesion, or from metastasis.The study of cellular differentiation, fibrosis, hyalinization, and lymphocytic infiltration was undertaken in an endeavor to determine the histologic factors causing the great variations in postoperative longevity (2, 3, 4, 5). Microscopic study of sections taken from many epitheliomas which were operable, and from others that were inoperable has revealed the presence of malignant cells taking on forms which closely resemble normal squamous-cell epithelium. They are well differentiated, as shown by the presence of pearly bodies. This phenomenon is termed cellular differentiation (fig. 1). In a great many of the cases the fibrous connective-tissue cells are seen working into and around the malignant tumor and apparently forming a barrier; this condition is known as fibrosis (fig. 2). Another phenomenon commonly seen is the presence of lymphocytes scattered intimately around the tumor cells, in some instances in such abundance that it is difficult to find the malignant cells. The abnormal presence of lymphocytes around a tumor is believed to be lymphocytic infiltration (fig. 3). A condition less commonly present is that of hyalinization (fig. 4) shown by a translucent or homogeneous condition of the connective tissue in and around the tumors." @default.
- W1490061807 created "2016-06-24" @default.
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- W1490061807 date "1922-10-01" @default.
- W1490061807 modified "2023-09-23" @default.
- W1490061807 title "The Relationship of Cellular Differentiation, Fibrosis, Hyalinization, and Lymphocytic Infiltration to Postoperative Longevity of Patients with Squamous-Cell Epithelioma of the Skin and Lip" @default.
- W1490061807 doi "https://doi.org/10.1158/jcr.1922.371" @default.
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