FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490179915> ?p ?o ?g. }

• W1490179915 endingPage "245" @default.
• W1490179915 startingPage "237" @default.
• W1490179915 abstract "We previously demonstrated a bimodal distribution of forearm vasodilator responsiveness to adenosine (ADO) infusion in the brachial arteries of human subjects. We also demonstrated that ADO receptor antagonism blunted exercise hyperaemia during heavy rhythmic handgripping, but vasodilator responses to exogenous ADO were only blunted in ADO responders. In this study, we continued investigating the contribution of ADO to exercise hyperaemia and possible differences between responders and non-responders. We hypothesized that ADO transporter antagonism would increase vasodilatation in response to exogenous ADO in responders only, but not effect exercise-mediated vasodilation. To test this hypothesis, we compared forearm vascular conductance (FVC) during infusion of ADO to FVC during handgripping before and after infusion of dipyridamole (DIP) in 20 subjects. In ADO responders, change in FVC above baseline (ml min−1 (100 mmHg)−1) for low, medium and high doses of ADO, respectively, was 58 ± 8, 121 ± 22 and 184 ± 38, and after DIP was 192 ± 32, 238 ± 50 and 310 ± 79. For non-responders, these values were 23 ± 2, 43 ± 5 and 66 ± 9, respectively, before DIP (P < 0.01 versus responders). Contrary to our hypothesis, these values were increased by DIP in non-responders (P < 0.001) and therefore not different from responders (P > 0.20). We found that ADO transporter blockade had no effect on exercise hyperaemia in either subgroup. We conclude that there may be increased ADO transporter activity in non-responders resulting in reduced ADO-mediated vasodilatation. The failure of DIP to augment exercise hyperemia under these conditions suggests that ADO concentrations may not rise enough during rhythmic handgripping to have a major impact on these responses." @default.
• W1490179915 created "2016-06-24" @default.
• W1490179915 creator A5002540006 @default.
• W1490179915 creator A5006738348 @default.
• W1490179915 creator A5031480179 @default.
• W1490179915 creator A5053447036 @default.
• W1490179915 creator A5057818152 @default.
• W1490179915 creator A5082946065 @default.
• W1490179915 date "2007-02-12" @default.
• W1490179915 modified "2023-10-18" @default.
• W1490179915 title "Adenosine transporter antagonism in humans augments vasodilator responsiveness to adenosine, but not exercise, in both adenosine responders and non-responders" @default.
• W1490179915 cites W151692802 @default.
• W1490179915 cites W1517594284 @default.
• W1490179915 cites W1548245910 @default.
• W1490179915 cites W1907106779 @default.
• W1490179915 cites W1969127237 @default.
• W1490179915 cites W1970152920 @default.
• W1490179915 cites W1974349880 @default.
• W1490179915 cites W1995497028 @default.
• W1490179915 cites W2015531406 @default.
• W1490179915 cites W2018725156 @default.
• W1490179915 cites W2022402604 @default.
• W1490179915 cites W2030958375 @default.
• W1490179915 cites W2037585389 @default.
• W1490179915 cites W2049660297 @default.
• W1490179915 cites W2064649750 @default.
• W1490179915 cites W2075988390 @default.
• W1490179915 cites W2082466944 @default.
• W1490179915 cites W2087309105 @default.
• W1490179915 cites W2087625710 @default.
• W1490179915 cites W2093880142 @default.
• W1490179915 cites W2096471937 @default.
• W1490179915 cites W2098686022 @default.
• W1490179915 cites W2115792507 @default.
• W1490179915 cites W2118819776 @default.
• W1490179915 cites W2149708400 @default.
• W1490179915 cites W2153322977 @default.
• W1490179915 cites W2159703114 @default.
• W1490179915 cites W2279199923 @default.
• W1490179915 cites W2334281876 @default.
• W1490179915 cites W2344144821 @default.
• W1490179915 cites W2402444000 @default.
• W1490179915 doi "https://doi.org/10.1113/jphysiol.2006.123000" @default.
• W1490179915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2075369" @default.
• W1490179915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17158170" @default.
• W1490179915 hasPublicationYear "2007" @default.
• W1490179915 type Work @default.
• W1490179915 sameAs 1490179915 @default.
• W1490179915 citedByCount "14" @default.
• W1490179915 countsByYear W14901799152012 @default.
• W1490179915 countsByYear W14901799152013 @default.
• W1490179915 countsByYear W14901799152015 @default.
• W1490179915 countsByYear W14901799152017 @default.
• W1490179915 countsByYear W14901799152019 @default.
• W1490179915 countsByYear W14901799152020 @default.
• W1490179915 crossrefType "journal-article" @default.
• W1490179915 hasAuthorship W1490179915A5002540006 @default.
• W1490179915 hasAuthorship W1490179915A5006738348 @default.
• W1490179915 hasAuthorship W1490179915A5031480179 @default.
• W1490179915 hasAuthorship W1490179915A5053447036 @default.
• W1490179915 hasAuthorship W1490179915A5057818152 @default.
• W1490179915 hasAuthorship W1490179915A5082946065 @default.
• W1490179915 hasBestOaLocation W14901799152 @default.
• W1490179915 hasConcept C120770815 @default.
• W1490179915 hasConcept C126322002 @default.
• W1490179915 hasConcept C134018914 @default.
• W1490179915 hasConcept C158846371 @default.
• W1490179915 hasConcept C164705383 @default.
• W1490179915 hasConcept C2776991684 @default.
• W1490179915 hasConcept C2777604165 @default.
• W1490179915 hasConcept C2777691872 @default.
• W1490179915 hasConcept C42219234 @default.
• W1490179915 hasConcept C71924100 @default.
• W1490179915 hasConcept C84393581 @default.
• W1490179915 hasConceptScore W1490179915C120770815 @default.
• W1490179915 hasConceptScore W1490179915C126322002 @default.
• W1490179915 hasConceptScore W1490179915C134018914 @default.
• W1490179915 hasConceptScore W1490179915C158846371 @default.
• W1490179915 hasConceptScore W1490179915C164705383 @default.
• W1490179915 hasConceptScore W1490179915C2776991684 @default.
• W1490179915 hasConceptScore W1490179915C2777604165 @default.
• W1490179915 hasConceptScore W1490179915C2777691872 @default.
• W1490179915 hasConceptScore W1490179915C42219234 @default.
• W1490179915 hasConceptScore W1490179915C71924100 @default.
• W1490179915 hasConceptScore W1490179915C84393581 @default.
• W1490179915 hasIssue "1" @default.
• W1490179915 hasLocation W14901799151 @default.
• W1490179915 hasLocation W14901799152 @default.
• W1490179915 hasLocation W14901799153 @default.
• W1490179915 hasOpenAccess W1490179915 @default.
• W1490179915 hasPrimaryLocation W14901799151 @default.
• W1490179915 hasRelatedWork W1490179915 @default.
• W1490179915 hasRelatedWork W1965943749 @default.
• W1490179915 hasRelatedWork W1992800516 @default.
• W1490179915 hasRelatedWork W2026105695 @default.
• W1490179915 hasRelatedWork W2056270585 @default.
• W1490179915 hasRelatedWork W2074641809 @default.
• W1490179915 hasRelatedWork W2111118530 @default.

• next