Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490255077> ?p ?o ?g. }
- W1490255077 endingPage "171" @default.
- W1490255077 startingPage "151" @default.
- W1490255077 abstract "Human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorder (HAND) is commonly associated with a multinucleated giant cell (MNGC) encephalitis termed HIV encephalitis (HIVE). Importantly, it occurs in most, but not all, cases of dementia related to HIV-1 infection. This chapter strives to describe what is known about multinuclear phagocytes (MP) activation and neuronal dysfunction with a focus on chemokines. Mounting evidence suggests that chemokines affect the pathogenesis of HAND. First, there is a state of “immune privilege” within the central nervous system (CNS) that is, in part, an evolutionary adaptation for which increasing evidence suggests that functional immunity is quite operative in the brain. Second, the maintenance of nervous system function requires protection from a variety of environmental insults occurring during inflammatory activities, such as HIVE. Third, chemokines (chemotactic cytokines) and chemokine receptors are an important part of the immune response that affects cell migration, activation, and tissue homeostasis. Fourth, following local production, chemokines induce leukocyte cytoskeletal changes, for example, actin polymerization, optimizing cell migration to areas of microbial infection or degeneration. Chemokine receptors are critical for the infection of perivascular macrophages and microglia. It has also been shown that chemokines and their receptors play a more direct role in the neuropathogenesis of HIV-1 infection. The neuropathogenesis of HIV-1 infection revolves around inflammatory factors secreted from virus-infected and immunocompetent brain MP. Chemokines and their chemokine receptors are expressed in the nervous system, and their engagement affects neuronal and glial function." @default.
- W1490255077 created "2016-06-24" @default.
- W1490255077 creator A5017340970 @default.
- W1490255077 creator A5028559857 @default.
- W1490255077 creator A5058974129 @default.
- W1490255077 creator A5073221937 @default.
- W1490255077 date "2014-04-09" @default.
- W1490255077 modified "2023-10-16" @default.
- W1490255077 title "Chemokines and the Neuropathogenesis of HIV-1 Infection" @default.
- W1490255077 cites W1487239329 @default.
- W1490255077 cites W1500985028 @default.
- W1490255077 cites W1506949828 @default.
- W1490255077 cites W1510310410 @default.
- W1490255077 cites W1522823711 @default.
- W1490255077 cites W1524482777 @default.
- W1490255077 cites W1525259648 @default.
- W1490255077 cites W1530364137 @default.
- W1490255077 cites W1535641516 @default.
- W1490255077 cites W1539836277 @default.
- W1490255077 cites W1540146056 @default.
- W1490255077 cites W1543084458 @default.
- W1490255077 cites W1557501694 @default.
- W1490255077 cites W1567845952 @default.
- W1490255077 cites W1581871973 @default.
- W1490255077 cites W1582483157 @default.
- W1490255077 cites W1585492421 @default.
- W1490255077 cites W1589337577 @default.
- W1490255077 cites W15977723 @default.
- W1490255077 cites W1600123087 @default.
- W1490255077 cites W1600863966 @default.
- W1490255077 cites W1611449349 @default.
- W1490255077 cites W1614954929 @default.
- W1490255077 cites W1638590376 @default.
- W1490255077 cites W1656832641 @default.
- W1490255077 cites W1679721892 @default.
- W1490255077 cites W1810051458 @default.
- W1490255077 cites W1817018401 @default.
- W1490255077 cites W1826650183 @default.
- W1490255077 cites W1868711871 @default.
- W1490255077 cites W1914391944 @default.
- W1490255077 cites W1959525771 @default.
- W1490255077 cites W1961326234 @default.
- W1490255077 cites W1963855922 @default.
- W1490255077 cites W1963903792 @default.
- W1490255077 cites W1963984954 @default.
- W1490255077 cites W1966157184 @default.
- W1490255077 cites W1968142538 @default.
- W1490255077 cites W1970239517 @default.
- W1490255077 cites W1971250957 @default.
- W1490255077 cites W1971731132 @default.
- W1490255077 cites W1973416063 @default.
- W1490255077 cites W1973432232 @default.
- W1490255077 cites W1974060304 @default.
- W1490255077 cites W1974521830 @default.
- W1490255077 cites W1974702421 @default.
- W1490255077 cites W1974955493 @default.
- W1490255077 cites W1976390944 @default.
- W1490255077 cites W1977386271 @default.
- W1490255077 cites W1977871435 @default.
- W1490255077 cites W1978795886 @default.
- W1490255077 cites W1979218462 @default.
- W1490255077 cites W1981376840 @default.
- W1490255077 cites W1981379366 @default.
- W1490255077 cites W1981440980 @default.
- W1490255077 cites W1981607446 @default.
- W1490255077 cites W1981644527 @default.
- W1490255077 cites W1982377759 @default.
- W1490255077 cites W1983287226 @default.
- W1490255077 cites W1984115097 @default.
- W1490255077 cites W1984811742 @default.
- W1490255077 cites W1987183930 @default.
- W1490255077 cites W1987871624 @default.
- W1490255077 cites W1988551550 @default.
- W1490255077 cites W1988632302 @default.
- W1490255077 cites W1988772884 @default.
- W1490255077 cites W1988867798 @default.
- W1490255077 cites W1988883119 @default.
- W1490255077 cites W1989035987 @default.
- W1490255077 cites W1991556620 @default.
- W1490255077 cites W1993182734 @default.
- W1490255077 cites W1993250333 @default.
- W1490255077 cites W1993387302 @default.
- W1490255077 cites W1993741557 @default.
- W1490255077 cites W1994254814 @default.
- W1490255077 cites W1994600662 @default.
- W1490255077 cites W1995905351 @default.
- W1490255077 cites W1995924099 @default.
- W1490255077 cites W1996851195 @default.
- W1490255077 cites W1996982755 @default.
- W1490255077 cites W1998529637 @default.
- W1490255077 cites W1999803078 @default.
- W1490255077 cites W2000673488 @default.
- W1490255077 cites W2000762235 @default.
- W1490255077 cites W2001142218 @default.
- W1490255077 cites W2002254372 @default.
- W1490255077 cites W2003615258 @default.
- W1490255077 cites W2004782459 @default.
- W1490255077 cites W2005091380 @default.