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- W1490263290 abstract "Cyclin-dependent protein kinases (CDKs) are required for various cell cycle events both in mitosis and in meiosis. During the meiotic prophase of Saccharomyces cerevisiae, only one CDK, Cdc28, which forms a complex with B-type cyclins, Clb5 or Clb6, promotes not only the onset of premeiotic DNA replication but also the formation of meiotic double-strand breaks (DSBs). In this study, we showed that Cdc28 exhibits punctate staining on chromosomes during meiotic prophase I. Chromosomal localization of Cdc28, dependent on Clb5 and/or Clb6, is frequently observed in zygotene and pachytene, when formation of the synaptonemal complex (SC) occurs. Interestingly, the CDK localization is independent of DSB formation, but rather dependent on meiosis-specific chromosome components such as Red1, Hop1 and a cohesin subunit Rec8. Compromised CDK activity in meiotic prophase leads to defective SC formation without affecting DSB formation. These results suggest that CDK-dependent phosphorylation regulates meiotic chromosome morphogenesis." @default.
- W1490263290 created "2016-06-24" @default.
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- W1490263290 date "2010-09-06" @default.
- W1490263290 modified "2023-09-25" @default.
- W1490263290 title "Cyclin-dependent kinase promotes formation of the synaptonemal complex in yeast meiosis" @default.
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- W1490263290 doi "https://doi.org/10.1111/j.1365-2443.2010.01440.x" @default.
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